Antiulcerogenic effects of 2 Maytenus species in laboratory-animals

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dc.contributor.authorSouza-Formigoni, Maria Lúcia Oliveira [UNIFESP]
dc.contributor.authorOliveira, Maria Gabriela M [UNIFESP]
dc.contributor.authorMonteiro, Maristela Goldnadel [UNIFESP]
dc.contributor.authorSilveira, Nilson Gomes da [UNIFESP]
dc.contributor.authorBraz, Sandra [UNIFESP]
dc.contributor.authorCarlini, E. A. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:58:46Z
dc.date.available2018-06-15T17:58:46Z
dc.date.issued1991-08-01
dc.description.abstractLeaves of Maytenus species are commonly used in Brazil for the treatment of gastric ulcers, dypepsias and other gastric problems. The present study evaluated the antiulcerogenic potential of a boiling water extract of equal parts of M. aquifolium and M. ilicifolia leaves against ulcer lesions induced by indomethacin and cold-restraint stress in rats. Ranitidine and cimetidine were used as reference drugs. The oral and intraperitoneal administration of the extract had a potent antiulcerogenic effect against both types of ulcers. The extract was shown to cause an increase in volume and pH of gastric juice of the animals with pH effects comparable to those of cimetidine. The results tend to confirm the popular use of the plant.en
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT PSYCHOBIOL,RUA BOTUCATU 862,1 ANDAR,CP 20399,BR-04034 SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT PSYCHOBIOL,RUA BOTUCATU 862,1 ANDAR,CP 20399,BR-04034 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent21-27
dc.identifierhttp://dx.doi.org/10.1016/0378-8741(91)90185-G
dc.identifier.citationJournal Of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 34, n. 1, p. 21-27, 1991.
dc.identifier.doi10.1016/0378-8741(91)90185-G
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44362
dc.identifier.wosWOS:A1991GD27200004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Ethnopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMAYTENUS SPECIESen
dc.subjectANTIULCEROGENIC EFFECTen
dc.subjectRATSen
dc.subjectGASTRIC ULCERSen
dc.subjectINDOMETHACINen
dc.subjectCOLD-RESTRAINT STRESSen
dc.titleAntiulcerogenic effects of 2 Maytenus species in laboratory-animalsen
dc.typeinfo:eu-repo/semantics/article
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