Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002

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dc.contributor.authorOhe, Monique Nakayama [UNIFESP]
dc.contributor.authorSantos, Rodrigo Oliveira [UNIFESP]
dc.contributor.authorBarros, Elizabete Ribeiro [UNIFESP]
dc.contributor.authorLage, Andrea Zacouteguy [UNIFESP]
dc.contributor.authorKunii, Ilda Sizue [UNIFESP]
dc.contributor.authorAbrahão, Márcio [UNIFESP]
dc.contributor.authorCervantes, Onivaldo [UNIFESP]
dc.contributor.authorHauache, Omar Magid [UNIFESP]
dc.contributor.authorLazaretti-Castro, Marise [UNIFESP]
dc.contributor.authorVieira, José Gilberto Henriques [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:31:43Z
dc.date.available2015-06-14T13:31:43Z
dc.date.issued2005-09-01
dc.description.abstractIn contrast to most developed countries, most patients with primary hyperparathyroidism in Brazil are still symptomatic at diagnosis. However, we have been observing a change in this pattern, especially in the last few years. We evaluated 104 patients, 77 females and 27 males aged 11-79 years (mean: 54.4 years), diagnosed between 1985 and 2002 at a University Hospital. Diagnosis was made on the basis of clinical findings and of high total and/or ionized calcium levels, high or inappropriate levels of intact parathyroid hormone and of surgical findings in 80 patients. Patients were divided into three groups, i.e., patients diagnosed from 1985 to 1989, patients diagnosed from 1990 to 1994, and patients diagnosed from 1995 to 2002. The number of new cases diagnosed/year increased from 1.8/year in the first group to 6.0/year in the second group and 8.1/year in the third group. The first group comprised 9 patients (mean serum calcium ± SD, 13.6 ± 1.6 mg/dl), 8 of them (88.8%) defined as symptomatic. The second group comprised 30 patients (mean calcium ± SD, 12.2 ± 1.63 mg/dl), 22 of them defined as symptomatic (73.3%). The third group contained 65 patients (mean calcium 11.7 ± 1.1 mg/dl), 34 of them symptomatic (52.3%). Patients from the first group tended to be younger (mean ± SD, 43.0 ± 15 vs 55.1 ± 14.4 and 55.7 ± 17.3 years, respectively) and their mean serum calcium was significantly higher (P < 0.05). All of symptomatic patients independent of group had higher serum calcium levels (12.4 ± 1.53 mg/dl, N = 64) than asymptomatic patients (11.4 ± 1.0 mg/dl, N = 40). Our data showed an increase in the percentage of asymptomatic patients over the years in the number of primary hyperparathyroidism cases diagnosed. This finding may be due to an increased availability of diagnostic methods and/or to an increased awareness about the disease.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Medicina
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.description.sourceSciELO
dc.format.extent1383-1387
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2005000900013
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 9, p. 1383-1387, 2005.
dc.identifier.doi10.1590/S0100-879X2005000900013
dc.identifier.fileS0100-879X2005000900013.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2005000900013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/2671
dc.identifier.wosWOS:000231773600013
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPrimary hyperparathyroidismen
dc.subjectHypercalcemiaen
dc.subjectClinical presentationen
dc.subjectAsymptomatic primary hyperparathyroidismen
dc.subjectParathyroid hormoneen
dc.subjectHyperparathyroidismen
dc.titleChanges in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002en
dc.typeinfo:eu-repo/semantics/article
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