The association between insulin resistance and depression in the Korean general population

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dc.citation.volume208
dc.contributor.authorLee, Jae-Hon
dc.contributor.authorPark, Sung Keun
dc.contributor.authorRyoo, Jae-Hong
dc.contributor.authorOh, Chang-Mo
dc.contributor.authorMansur, Rodrigo B. [UNIFESP]
dc.contributor.authorAlfonsi, Jeffrey E.
dc.contributor.authorCha, Danielle S.
dc.contributor.authorLee, Yena
dc.contributor.authorMcIntyre, Roger S.
dc.contributor.authorJung, Ju Young
dc.coverageAmsterdam
dc.date.accessioned2020-07-17T14:03:14Z
dc.date.available2020-07-17T14:03:14Z
dc.date.issued2017
dc.description.abstractBackground: Previous studies showed that the insulin resistance (IR) could be related to depression. However, this association is still equivocal in the general population. Herein, we aimed to investigate the association between IR and depressive symptoms in a large sample in South Korea. Methods: A cross-sectional study was carried out for 165,443 Korean men and women who received a health checkup including various clinical parameters and the Center for Epidemiologic Studies Depression scales (CES-D). Subjects were stratified into subgroups by CES-D score, sex, age, and presence of diabetes. The odd ratios (ORs) for homeostasis model assessment of insulin resistance (HOMA-IR) were compared between groups using multivariable logistic regression analyses. Results: After adjusting covariates (e.g. smoking, family income, marriage state, unemployment status, average alcohol use, BMI, physical activity, systolic blood pressure, diabetes), increased IR was weakly associated with greater depressive symptoms (adjusted OR=1.01 [95% CI 1.0001-1.03]). Subgroup analysis revealed this association was statistically significant in females (adjusted OR-1.03, [95% CI 1.001-1.06]), non-diabetic group (adjusted OR-1.04, [95% CI 1.02-1.06]), and young participants under the age of thirty (adjusted OR-1.17, [95% CI 1.07-1.27]). But we couldn't find significant association in diabetic and middle to elderly participants. Conclusions: This study demonstrates that there is a relationship between IR and depressive symptoms in the Korean general population. Results from this epidemiological study revealed that young adults and non-diabetic individuals with increased IR may be related with depressive symptoms.en
dc.description.affiliationUniv Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada
dc.description.affiliationSungkyunkwan Univ, Sch Med, Samsung Seoul Hosp, Dept Psychiat, Seoul, South Korea
dc.description.affiliationSungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Total Healthcare Ctr, Seoul, South Korea
dc.description.affiliationKyung Hee Univ, Sch Med, Dept Prevent Med, Seoul, South Korea
dc.description.affiliationNatl Canc Ctr, Natl Canc Control Inst, Canc Registrat & Stat Branch, Goyang, South Korea
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LING, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Western Ontario, Schulich Sch Med & Dent, Dept Med, London, ON N6A 3K7, Canada
dc.description.affiliationUniv Toronto, Inst Med Sci, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Dept Pharmacol, Toronto, ON M5S 1A1, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LING, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP, Brazil
dc.description.sponsorshipLundbeck, Canada
dc.description.sponsorshipLundbeck
dc.description.sponsorshipJanssenOrtho
dc.description.sponsorshipShire
dc.description.sponsorshipPurdue
dc.description.sponsorshipAstraZeneca
dc.description.sponsorshipPfizer
dc.description.sponsorshipOtsuka
dc.description.sponsorshipAllergan
dc.description.sponsorshipStanley Medical Research Institute (SMRI)
dc.description.sponsorshipElli-Lilly
dc.description.sponsorshipJohnson Johnson
dc.description.sponsorshipMoksha8
dc.description.sponsorshipSunovion
dc.description.sponsorshipMitsubishi
dc.description.sponsorshipTakeda
dc.description.sponsorshipForest
dc.description.sponsorshipBristol-Myers Squibb
dc.format.extent553-559
dc.identifierhttp://dx.doi.org/10.1016/j.jad.2016.10.027
dc.identifier.citationJournal Of Affective Disorders. Amsterdam, v. 208, p. 553-559, 2017.
dc.identifier.doi10.1016/j.jad.2016.10.027
dc.identifier.issn0165-0327
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55249
dc.identifier.wosWOS:000390732600079
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal Of Affective Disorders
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDepressionen
dc.subjectInsulin resistanceen
dc.subjectCross-sectional studyen
dc.subjectGeneral populationen
dc.titleThe association between insulin resistance and depression in the Korean general populationen
dc.typeinfo:eu-repo/semantics/article
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