Cardiovascular and Renal Effects of Birdseed Associated with Aerobic Exercise in Rats

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dc.citation.issue10
dc.citation.volume48
dc.contributor.authorPassos, Clevia Santos [UNIFESP]
dc.contributor.authorRibeiro, Rosemara Silva [UNIFESP]
dc.contributor.authorRosa, Thiago Santos
dc.contributor.authorNeves, Rodrigo Vanerson Passos [UNIFESP]
dc.contributor.authorCosta, Fernando [UNIFESP]
dc.contributor.authorGinoza, Milton [UNIFESP]
dc.contributor.authorBoim, Mirian Aparecida [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-07-31T12:47:41Z
dc.date.available2020-07-31T12:47:41Z
dc.date.issued2016
dc.description.abstractIntroductionPhalaris canariensis L. (Pc), known as birdseed, is rich in tryptophan. The aqueous extract of Pc (AEPc) treatment reduced systolic blood pressure (SBP) in spontaneously hypertensive rats (SHR) via mechanisms mediated by the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase (IDO). Hypertension is a risk factor to cardiovascular and renal diseases. Considering that physical exercise improves hypertension and cardiovascular function, the aim of this study was to evaluate whether the benefits of exercise (Ex) would be enhanced by concomitant AEPc treatment (400 mgkg(-1)d(-1) p.o.). Methods Vascular reactivity was assessed in aorta rings from SHR treated with AEPc for 4 wk. Training intensity was based on maximal lactate steady state obtained during the 2-wk adaptation period in a treadmill running. Then exercised (60 min running, five times per week during 8 wk) or sedentary SHR were untreated or treated with AEPc during 8 wk. SBP was estimated by plethysmograph. Heart mass and body mass were used to obtain the index of cardiac hypertrophy. Glucose tolerance test was evaluated by oral glucose overload, and the mRNA expressions of indoleamine 2,3-dioxygenase, interleukin 1 (IL-1), and IL-10 in the kidney were obtained by real time polymerase chain reaction. Results AEPc induced endothelial-mediated vascular relaxation. AEPc or Ex alone reduced SBP, the index of cardiac hypertrophy and ventricular fibrosis, improved glucose metabolism, and attenuated proteinuria and the renal expression of the proinflammatory IL-1 with an overexpression in the anti-inflammatory IL-10. AEPc potentiated the benefits of the Ex on the cardiovascular system, metabolic parameters, and renal inflammation. Conclusion Birdseed reduced cardiovascular risk related to hypertension and had positive effects when associated to physical exercise.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Div Renal, Sao Paulo, Brazil
dc.description.affiliationUniv Catolica Brasilia, Grad Program Phys Educ & Hlth, Brasilia, DF, Brazil
dc.description.affiliationUnifespRenal Division, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, BRAZIL
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação Oswaldo Ramos (FOR)
dc.format.extent1925-1934
dc.identifierhttp://dx.doi.org/10.1249/MSS.0000000000000995
dc.identifier.citationMedicine And Science In Sports And Exercise. Philadelphia, v. 48, n. 10, p. 1925-1934, 2016.
dc.identifier.doi10.1249/MSS.0000000000000995
dc.identifier.issn0195-9131
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57011
dc.identifier.wosWOS:000384298800009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine And Science In Sports And Exercise
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHYPERTENSIONen
dc.subjectTRYPTOPHANen
dc.subjectKIDNEYen
dc.subjectPHALARIS CANARIENSISen
dc.subjectCYTOKINESen
dc.subjectRUNNINGen
dc.titleCardiovascular and Renal Effects of Birdseed Associated with Aerobic Exercise in Ratsen
dc.typeinfo:eu-repo/semantics/article
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