Sexual transmission of HIV-1 isolate showing G -> A hypermutation

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dc.contributor.authorCaride, E.
dc.contributor.authorBrindeiro, R. M.
dc.contributor.authorKallas, Esper Georges [UNIFESP]
dc.contributor.authorSa, CAM de
dc.contributor.authorEyer-Silva, W. A.
dc.contributor.authorMachado, E.
dc.contributor.authorTanuri, A.
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Univ Gaffree & Guinle
dc.date.accessioned2016-01-24T12:33:11Z
dc.date.available2016-01-24T12:33:11Z
dc.date.issued2002-01-01
dc.description.abstractRetroviral genomes with a high frequency of G --> A mutations are thought to originate during reverse transcription (RT). Here we present a case report of an AIDS patient infected with a subtype F variant where extensive G --> A hypermutation (G --> A Hypm) sequences were found in the protease gene. This patient was failing HAART at the time the hypermutation was found. These sequences were basically encountered in the proviral compartment on two occasions and were persistently absent in the plasma viral population. the patient's viral genotype showed several mutations related to antiretroviral drug resistance in RT (T69N, N184V, T215F, K219Q) and protease (M36I, G48V, I54V, T63L, V82A) genes. the drug regimen was changed and the viral load dropped 0.9 Logs and CD4 count increased by 200 cells/ml. the hypermutation was not found any more in a 1-year follow up. the patient's wife was infected with a similar virus strain and G A Hypm sequences were also detected in the RT gene. This is the first report of sexual transmitted G --> A Hypermutation in HIV-1 and suggest that this phenomenon can be genetically coded by the viral RT molecule. (C) 2002 Elsevier Science B.V. All rights reserved.en
dc.description.affiliationUniv Fed Rio de Janeiro, Mol Virol Lab, Dept Genet, BR-21944970 Rio de Janeiro, Brazil
dc.description.affiliationUFESP, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationHosp Univ Gaffree & Guinle, Rio de Janeiro, Brazil
dc.description.affiliationUFRJ, Hosp Univ Clementino Fraga Filho, Rio de Janeiro, Brazil
dc.description.affiliationUnifespUNIFESP, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent179-189
dc.identifierhttp://dx.doi.org/10.1016/S1386-6532(01)00218-9
dc.identifier.citationJournal of Clinical Virology. Amsterdam: Elsevier B.V., v. 23, n. 3, p. 179-189, 2002.
dc.identifier.doi10.1016/S1386-6532(01)00218-9
dc.identifier.issn1386-6532
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26707
dc.identifier.wosWOS:000173240800006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Clinical Virology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectHIV-1en
dc.subjectG -> A hypermutationen
dc.subjectproteaseen
dc.subjectreverse transcriptaseen
dc.subjectHAARTen
dc.subjectCD4+T cellsen
dc.subjectoligoclonal expansionen
dc.titleSexual transmission of HIV-1 isolate showing G -> A hypermutationen
dc.typeinfo:eu-repo/semantics/article
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