Involvement of the opioid system in the development and expression of sensitization to the locomotor-activating effect of ethanol

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dc.contributor.authorCamarini, Rosana [UNIFESP]
dc.contributor.authorPires, Maria Laura Nogueira [UNIFESP]
dc.contributor.authorCalil, Helena Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Calif San Francisco
dc.contributor.institutionOregon Hlth Sci Univ
dc.date.accessioned2016-01-24T12:31:13Z
dc.date.available2016-01-24T12:31:13Z
dc.date.issued2000-12-01
dc.description.abstractPrevious studies have shown that pretreatment with naloxone (Nlx), an opiate antagonist, attenuates the stimulating effect of ethanol. the purpose of the present study was to determine the influence of Nix on the development and expression of the sensitization to ethanol. Initially, effects of different doses of Nix on the response to a low dose of ethanol (2.0 g/kg) were assessed. Nix (1.0 and 3.0 mg/kg i.p.) decreased the stimulating effect of ethanol. Groups of mice were treated with saline or Nix (1.0 mg/kg i.p.) plus saline or ethanol (2.0 g/kg if) during 21 d. On day 25 of treatment all animals received an ethanol challenge (2.0 g/kg i.p.). It significantly increased the locomotor activity of mice that had received chronic ethanol (2.0 g/kg) once daily as compared to those that had received saline. Chronic administration of Nlx (1.0 mg/kg i.p.), during the same period of time, did not change the locomotor activity of the mice. However, the group concomitantly treated with Nix + ethanol did not develop sensitization to the locomotor-activating effect of ethanol. Another experiment was carried out to determine the effects of Nix on the expression of sensitization to ethanol. Acute pretreatment with Nix did not change the response of the mice that had developed sensitization to ethanol. These data show Nix's prevention of the development of ethanol-induced sensitization but not of its expression, suggesting an important role of the opioid neurotransmitter systems modulating the development of sensitization to the locomotor-activating effect of ethanol.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
dc.description.affiliationUniv Calif San Francisco, Gallo Ctr, San Francisco, CA 94143 USA
dc.description.affiliationOregon Hlth Sci Univ, Portland, OR 97201 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent303-309
dc.identifierhttp://dx.doi.org/10.1017/S146114570000211X
dc.identifier.citationInternational Journal of Neuropsychopharmacology. New York: Cambridge Univ Press, v. 3, n. 4, p. 303-309, 2000.
dc.identifier.doi10.1017/S146114570000211X
dc.identifier.issn1461-1457
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26417
dc.identifier.wosWOS:000166252100004
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofInternational Journal of Neuropsychopharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectethanolen
dc.subjectnaloxoneen
dc.subjectsensitizationen
dc.subjectopioid systemsen
dc.titleInvolvement of the opioid system in the development and expression of sensitization to the locomotor-activating effect of ethanolen
dc.typeinfo:eu-repo/semantics/article
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