Subchronical treatment with Fluoxetine modifies the activity of the MCHergic and hypocretinergic systems. Evidences from peptide CSF concentration and gene expression

dc.citation.issue2
dc.citation.volume9
dc.contributor.authorCalegare, Bruno F. [UNIFESP]
dc.contributor.authorCosta, Alicia
dc.contributor.authorFernandes, Leandro [UNIFESP]
dc.contributor.authorDias, Ana L. [UNIFESP]
dc.contributor.authorTorterolo, Pablo
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-08-21T16:59:46Z
dc.date.available2020-08-21T16:59:46Z
dc.date.issued2016
dc.description.abstractIn the postero-lateral hypothalamus are located two neuronal systems that utilize the neuropeptides melanin-concentrating hormone (MCH) and hypocretins (also called orexins) as neuromodulators. These systems have reciprocal connections between them, and project throughout the central nervous system. MCH has been involved in the generation of sleep, mainly REM sleep, while hypocretins have a critical role in the generation of wakefulness. MCHergic activity is also involved in the pathophysiology of major depressive disorder (MD). In this regards, intracerebral administration of MCH promotes pro-depressive behaviors (i.e., immobility in the forced swimming test) and REM sleep hypersomnia, which is an important trait of depression. Furthermore, the antagonism of the MCHR-1 receptor has a reliable antidepressant effect, suggesting that MCH is a pro-depressive factor. Hypocretins have been also involved in mood regulation; however, their role in depression is still on debate. Taking these data into account, we explored whether systemic subchronical treatment with Fluoxetine (FLX), a serotonergic antidepressant, modifies the concentration of MCH in the cerebrospinal fluid (CSF), as well as the preproMCH mRNA expression. We also evaluated the hypocretinergic system by quantifying the hypocretin-levels in the CSF and the preprohypocretin mRNA expression. Compared to control, FLX increased the levels of preprohypocretin mRNA without affecting the hypocretin-1 CSF levels. On the contrary, FLX significantly decreased the MCH CSF concentration without affecting the preproMCH gene expression. This result is in agreement with the fact that MCH serum level diminishes during the antidepressant treatment in MD, and supports the hypothesis that an increase in the MCHergic activity could have pro-depressive consequences. (C) 2016 Brazilian Association of Sleep. Production and Hosting by Elsevier B.V.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUniv Republica, Dept Physiol, Sch Med, Montevideo, Uruguay
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipProyecto de Cooperacion Bilateral Uruguay- Brasil, Dicyt-CNPq
dc.description.sponsorshipPrograma de Desarrollo de Ciencias Basicas (PEDECIBA)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipIDProyecto de Cooperacion Bilateral Uruguay- Brasil, Dicyt-CNPq: ANII-FCE-1-2011-1-5997
dc.format.extent89-93
dc.identifierhttp://dx.doi.org/10.1016/j.slsci.2016.05.010
dc.identifier.citationSleep Science. Amsterdam, v. 9, n. 2, p. 89-93, 2016.
dc.identifier.doi10.1016/j.slsci.2016.05.010
dc.identifier.fileWOS000399919100009.pdf
dc.identifier.issn1984-0659
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57760
dc.identifier.wosWOS:000399919100009
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofSleep Science
dc.rightsAcesso aberto
dc.subjectNeuropeptidesen
dc.subjectHypocretinen
dc.subjectOrexinen
dc.subjectDepressionen
dc.subjectAntidepressanten
dc.subjectMelanin-concentrating hormoneen
dc.titleSubchronical treatment with Fluoxetine modifies the activity of the MCHergic and hypocretinergic systems. Evidences from peptide CSF concentration and gene expressionen
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