Adrenocorticotropin-producing pituitary carcinoma with expression of c-erbB-2 and high PCNA index: A comparative study with pituitary adenomas and normal pituitary tissues

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dc.contributor.authorNose-Alberti, V
dc.contributor.authorMesquita, MIS
dc.contributor.authorMartin, L. C.
dc.contributor.authorKayath, M. J.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:33Z
dc.date.available2016-01-24T12:30:33Z
dc.date.issued1998-03-01
dc.description.abstractPituitary carcinomas are very rare neoplasms with a poor prognosis. We report a case of Cushing's disease resulting from a pituitary carcinoma in a ZZ-yr-old female, who died of massive hepatic failure. At autopsy, there was invasion of the parasellar structures and vasculature by the tumor, which stained positively only for ACTH. There were two metastatic nodules in the liver, which also stained positively for ACTH. When compared to other cases of Cushing's disease (n = 52), other pituitary adenomas (n = 292), and normal pituitary tissues (n = 21), the pituitary carcinoma was the only one with c-erbB-2 membrane staining in both the sellar-located tissue and liver metastasis. C-erbB-2 staining was present in the cytoplasm of a variable number of cells in 40% of the invasive adenomas (n = 103), while only 1.2% of the noninvasive tumors (n = 241) expressed this protein (p < 0.001). No particular immunohistological type preferentially expressed this protein. in normal pituitary tissues, 10% of the cells expressed cytoplasmic c-erbB-2. A higher index of proliferating cell nuclear antigen (PCNA) in the primary tumor and liver metastasis (10%) was also found compared to other ACTH-secreting adenomas (invasive, 3.4 +/- 1.9% vs 1.7 +/- 1.5% in noninvasive) and other pituitary tumors (invasive, 2.9 +/- 1.5% vs 1.5 +/- 1.3% in noninvasive). the PCNA index was significantly higher in invasive tumors than in noninvasive adenomas (p = 0.004). PCNA staining was negative in normal pituitary tissues. Staining for p53, pRB and p(21ras) was negative in the carcinoma and liver metastasis. We suggest that the c-erbB-2 membrane pattern and a higher PCNA index may indicate a worse prognosis in adenohypophyseal neoplasia.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Div Endocrinol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Div Endocrinol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent53-62
dc.identifierhttp://dx.doi.org/10.1007/BF02739952
dc.identifier.citationEndocrine Pathology. Totowa: Humana Press Inc, v. 9, n. 1, p. 53-62, 1998.
dc.identifier.doi10.1007/BF02739952
dc.identifier.issn1046-3976
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25871
dc.identifier.wosWOS:000074511100007
dc.language.isoeng
dc.publisherHumana Press Inc
dc.relation.ispartofEndocrine Pathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectpituitary carcinomaen
dc.subjectCushing's syndromeen
dc.subjectACTHen
dc.subjectc-erbB-2en
dc.subjectPCNAen
dc.subjectp53en
dc.subjectp(21ras)en
dc.titleAdrenocorticotropin-producing pituitary carcinoma with expression of c-erbB-2 and high PCNA index: A comparative study with pituitary adenomas and normal pituitary tissuesen
dc.typeinfo:eu-repo/semantics/article
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