From autoantibody research to standardized diagnostic assays in the management of human diseases - report of the 12th Dresden Symposium on Autoantibodies

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dc.citation.issue8
dc.citation.volume25
dc.contributor.authorConrad, K.
dc.contributor.authorAndrade, L. E. C. [UNIFESP]
dc.contributor.authorChan, E. K. L.
dc.contributor.authorMahler, M.
dc.contributor.authorMeroni, P. L.
dc.contributor.authorPruijn, G. J. M.
dc.contributor.authorSteiner, G.
dc.contributor.authorShoenfeld, Y.
dc.coverageLondon
dc.date.accessioned2020-08-14T13:44:27Z
dc.date.available2020-08-14T13:44:27Z
dc.date.issued2016
dc.description.abstractTesting for autoantibodies (AABs) is becoming more and more relevant, not only for diagnosing autoimmune diseases (AIDs) but also for the differentiation of defined AID subtypes with different clinical manifestations, course and prognosis as well as the very early diagnosis for adequate management in the context of personalized medicine. A major challenge to improve diagnostic accuracy is to harmonize or even standardize AAB analyses. This review presents the results of the 12th Dresden Symposium on Autoantibodies that focused on several aspects of improving autoimmune diagnostics. Topics that are addressed include the International Consensus on ANA Patterns (ICAP) and the International Autoantibody Standardization (IAS) initiatives, the optimization of diagnostic algorithms, the description and evaluation of novel disease-specific AABs as well as the development and introduction of novel assays into routine diagnostics. This review also highlights important developments of recent years, most notably the improvement in diagnosing and predicting the course of rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, and of autoimmune neurological, gastrointestinal and liver diseasesen
dc.description.abstractthe potential diagnostic role of anti-DFS70 antibodies and tumor-associated AABs. Furthermore, some hot topics in autoimmunity regarding disease pathogenesis and management are described.en
dc.description.affiliationTech Univ Dresden, Inst Immunol, Fac Med, Fetscherstr 74, D-01307 Dresden, Germany
dc.description.affiliationUniv Fed Sao Paulo, Div Rheumatol, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationFleury Med & Hlth Labs, Div Immunol, Sao Paulo, Brazil
dc.description.affiliationUniv Florida, Dept Oral Biol, Gainesville, FL 32610 USA
dc.description.affiliationINOVA Diagnost Inc, San Diego, CA USA
dc.description.affiliationUniv Milan, Dept Clin Sci & Community Hlth, Lab Immunorheumatol Res, Ist Auxol Italiano, Milan, Italy
dc.description.affiliationRadboud Univ Nijmegen, Dept Biomol Chem, NL-6525 ED Nijmegen, Netherlands
dc.description.affiliationMed Univ Vienna, Dept Rheumatol, Internal Med 3, Vienna, Austria
dc.description.affiliationTel Aviv Univ, Sheba Med Ctr, Sackler Fac Med, Tel Aviv, Israel
dc.description.affiliationSheba Med Ctr, Zabludowicz Ctr Autoimmune Dis, Tel Hashomer, Israel
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Rheumatol, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent787-796
dc.identifierhttp://dx.doi.org/10.1177/0961203316644337
dc.identifier.citationLupus. London, v. 25, n. 8, p. 787-796, 2016.
dc.identifier.doi10.1177/0961203316644337
dc.identifier.issn0961-2033
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57679
dc.identifier.wosWOS:000379238100001
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofLupus
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectANAen
dc.subjectautoantibodiesen
dc.subjectautoimmune diseasesen
dc.subjectautoimmunityen
dc.subjectdiagnosticsen
dc.subjectstandardizationen
dc.titleFrom autoantibody research to standardized diagnostic assays in the management of human diseases - report of the 12th Dresden Symposium on Autoantibodiesen
dc.typeinfo:eu-repo/semantics/article
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