Lipid peroxidation and antioxidants in hyperlipidemia and hypertension

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dc.contributor.authorMoriel, Patricia
dc.contributor.authorPlavnik, Frida Liane [UNIFESP]
dc.contributor.authorZanella, Maria Teresa [UNIFESP]
dc.contributor.authorBertolami, Marcelo Chiara [UNIFESP]
dc.contributor.authorAbdalla, Dulcineia Saes Parra [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Dante Pazzanese Cardiol
dc.date.accessioned2018-06-15T14:04:25Z
dc.date.available2018-06-15T14:04:25Z
dc.date.issued2000-01-01
dc.description.abstractLipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. To clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of LDL, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (HC), hypertensive (H), hypercholesterolemic/hypertensive (HH) and normolipidemic/normotensive subjects (N). Plasma ascorbate and lipid-soluble antioxidants were lower, while LDL oxidizability, CE-OOH and TL-OOH were higher in H, HC, and HH groups than in the N group. No difference was observed among groups for PL-OOH and isoprostanes. In summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the LDL susceptibility to oxidation were higher; 2) total cholesterol, LDL-cholesterol, apoB and CE-OOH were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of LDL to oxidation; and 3) CE-OOH and TL-OOH were positively correlated with total cholesterol and LDL-cholesterol.en
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut, Dept Clin & Toxicol Anal, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Hosp Rim, Dept Nefrol, Sao Paulo, Brazil
dc.description.affiliationInst Dante Pazzanese Cardiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Hosp Rim, Dept Nefrol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent105-112
dc.identifierhttp://dx.doi.org/10.4067/S0716-97602000000200010
dc.identifier.citationBiological Research. Santiago: Sociedad Biolgia Chile, v. 33, n. 2, p. 105-112, 2000.
dc.identifier.doi10.4067/S0716-97602000000200010
dc.identifier.issn0716-9760
dc.identifier.scieloS0716-97602000000200010
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42824
dc.identifier.wosWOS:000165303700008
dc.language.isoeng
dc.publisherSociedad Biolgia Chile
dc.relation.ispartofBiological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectlipoprotein oxidationen
dc.subjectlipid peroxidesen
dc.subjectisoprostanesen
dc.subjectantioxidantsen
dc.subjectatherosclerosisen
dc.subjectoxidative stressen
dc.titleLipid peroxidation and antioxidants in hyperlipidemia and hypertensionen
dc.typeinfo:eu-repo/semantics/article
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