Quantitation of soluble E-receptor of T lymphocytes in serum from HIV-1 positive patients

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dc.contributor.authorNunez, G.
dc.contributor.authorMoura, N. C.
dc.contributor.authorHernandez, H. J.
dc.contributor.authorPeixinho, Z. F.
dc.contributor.authorZeballos, R. S.
dc.contributor.authorCavalcante, N.
dc.contributor.authorFlores, P.
dc.contributor.authorLongo, I. M.
dc.contributor.authorMendes, N. F.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:36Z
dc.date.available2016-01-24T11:40:36Z
dc.date.issued1997-01-01
dc.description.abstractHuman T lymphocytes carry a membrane receptor for sheep erythrocytes (E) related to the CD2 molecule. the E-receptor is found in a soluble form (Rs) in serum and can be quantitated by ''rocket electrophoresis'' using an anti-Rs serum obtained by immunizing sheep with autologous erythrocytes coated with Rs. Increased serum levels of Rs are found in patients with diseases associated with immunodepression. in the present study, 14 asymptomatic HIV-1 seropositive individuals were investigated regarding their Rs levels and delayed hypersensitivity skin tests every 3 months for a period of 35 months. All these patients progressed to AIDS in this period. Rs serum levels have also been quantitated in 14 normal individuals. the mean Rs values in normal individuals, asymptomatic, and AIDS patients were, respectively: 4.8 +/- 1.5 mm (SD), 9.6 +/- 1.9 mm (SD) and 11.3 +/- 2.4 mm (SD). An increase of Rs serum levels was observed when we compared normal individuals with CDC-II and CDC-IV clinical stage patients (P less-than 0.05, Mann-Whitney test) and CDC-II and CDC-IV patients, (P less-than 0.05, wilcoxon test). We have observed a depressed delayed hypersensitivity response to ubiquitous antigens in CDC-IV patients. Our results indicate that Rs serum levels can be used as a progression marker in HIV infected patients. J. Clin. Lab. Anal. 11:69-72.en
dc.description.affiliationUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT MICROBIOL IMUNOL & PARASITOL,BR-04038990 São Paulo,SP,BRAZIL
dc.description.affiliationUnifespUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT MICROBIOL IMUNOL & PARASITOL,BR-04038990 São Paulo,SP,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent69-72
dc.identifierhttp://dx.doi.org/10.1002/(SICI)1098-2825(1997)11:1<69
dc.identifier.citationJournal of Clinical Laboratory Analysis. New York: Wiley-liss, v. 11, n. 1, p. 69-72, 1997.
dc.identifier.doi10.1002/(SICI)1098-2825(1997)11:1<69
dc.identifier.issn0887-8013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25653
dc.identifier.wosWOS:A1997WF10500010
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectCD2en
dc.subjectAIDSen
dc.subjectretrovirusen
dc.titleQuantitation of soluble E-receptor of T lymphocytes in serum from HIV-1 positive patientsen
dc.typeinfo:eu-repo/semantics/article
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