Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients

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dc.contributor.authorGroehs, Raphaela Vilar
dc.contributor.authorToschi-Dias, Edgar
dc.contributor.authorAntunes-Correa, Ligia de Moraes
dc.contributor.authorTrevizan, Patricia Fernandes
dc.contributor.authorRondon, Maria Urbana Pinto Brandão
dc.contributor.authorOliveira, Patricia
dc.contributor.authorAlves, Maria Janieire de Nazaré Nunes
dc.contributor.authorAlmeida, Dirceu Rodrigues de [UNIFESP]
dc.contributor.authorMiddlekauff, Holly R.
dc.contributor.authorNegrao, Carlos Eduardo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Calif Los Angeles
dc.date.accessioned2016-01-24T14:40:25Z
dc.date.available2016-01-24T14:40:25Z
dc.date.issued2015-05-01
dc.description.abstractArterial baroreflex control of muscle sympathetic nerve activity (ABRMSNA) is impaired in chronic systolic heart failure (CHF). the purpose of the study was to test the hypothesis that exercise training would improve the gain and reduce the time delay of ABRMSNA in CHF patients. Twenty-six CHF patients, New York Heart Association Functional Class II-III, EF <= 40%, peak (V) over dot O-2 <= 20 ml.kg(-1).min(-1) were divided into two groups: untrained (UT, n = 13, 57 +/- 3 years) and exercise trained (ET, n = 13, 49 +/- 3 years). Muscle sympathetic nerve activity (MSNA) was directly recorded by microneurography technique. Arterial pressure was measured on a beat-to-beat basis. Time series of MSNA and systolic arterial pressure were analyzed by autoregressive spectral analysis. the gain and time delay of ABRMSNA was obtained by bivariate autoregressive analysis. Exercise training was performed on a cycle ergometer at moderate intensity, three 60-min sessions per week for 16 wk. Baseline MSNA, gain and time delay of ABRMSNA, and low frequency of MSNA (LFMSNA) to high-frequency ratio (HFMSNA) (LFMSNA/HFMSNA) were similar between groups. ET significantly decreased MSNA. MSNA was unchanged in the UT patients. the gain and time delay of ABRMSNA were unchanged in the ET patients. in contrast, the gain of ABRMSNA was significantly reduced [3.5 +/- 0.7 vs. 1.8 +/- 0.2, arbitrary units (au)/mmHg, P = 0.04] and the time delay of ABRMSNA was significantly increased (4.6 +/- 0.8 vs. 7.9 +/- 1.0 s, P = 0.05) in the UT patients. LFMSNA-to-HFMSNA ratio tended to be lower in the ET patients (P < 0.08). Exercise training prevents the deterioration of ABRMSNA in CHF patients.en
dc.description.affiliationUniv São Paulo, Sch Med, Heart Inst InCor, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Phys Educ & Sport, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUniv Calif Los Angeles, David Geffen Sch Med, Dept Med Cardiol & Physiol, Los Angeles, CA 90095 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipFundação Zerbinipt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipNational Heart, Lung, and Blood Institute
dc.description.sponsorshipIDFAPESP: 2010/50048-1pt
dc.description.sponsorshipIDFAPESP: 140643/2009-5pt
dc.description.sponsorshipIDFAPESP: 2013/07651-7pt
dc.description.sponsorshipIDCNPq: 142366/2009-9pt
dc.description.sponsorshipIDCNPq: 301867/2010-0pt
dc.description.sponsorshipIDCNPq: 308068/2011-4pt
dc.description.sponsorshipIDFAPESP: 2013/15651-7pt
dc.description.sponsorshipIDNational Heart, Lung, and Blood Institute: RO1-HL084525
dc.format.extentH1096-H1102
dc.identifierhttps://dx.doi.org/10.1152/ajpheart.00723.2014
dc.identifier.citationAmerican Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 308, n. 9, p. H1096-H1102, 2015.
dc.identifier.doi10.1152/ajpheart.00723.2014
dc.identifier.issn0363-6135
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/39017
dc.identifier.wosWOS:000353959000017
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology-heart and Circulatory Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic heart failureen
dc.subjectSympathetic modulationen
dc.subjectArterial baroreflex controlen
dc.subjectExercise trainingen
dc.titleExercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patientsen
dc.typeinfo:eu-repo/semantics/article
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