Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir

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dc.contributor.authorMachado, Daisy Maria [UNIFESP]
dc.contributor.authorGouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]
dc.contributor.authorCardoso, Maria Regina
dc.contributor.authorBeltrão, Suênia Vasconcelos [UNIFESP]
dc.contributor.authorCunegundes, Kelly Simone [UNIFESP]
dc.contributor.authorBononi, Fabiana [UNIFESP]
dc.contributor.authorAlmeida, Fernanda [UNIFESP]
dc.contributor.authorCavalheiro, Kaline [UNIFESP]
dc.contributor.authorAngelis, Daniela Souza Araújo de
dc.contributor.authorSucci, Regina Célia de Menezes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSão Paulo University Faculty of Public Health
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-06-14T13:36:41Z
dc.date.available2015-06-14T13:36:41Z
dc.date.issued2007-02-01
dc.description.abstractThis study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children. The study included 29 Brazilian children (median age = 5.91 years) who had failed previous ARV therapy and had begun a regimen based on LPV/r. At 12 months follow-up, a good virological response to LPV/r therapy was defined as achieving an undetectable viral load or as a decrease in plasma HIV RNA levels to > 1 log. A good immunological response was defined as an increase in CD4+ cell count from baseline sufficient to attain a better CDC immune stage classification. The number of infectious episodes 12 months before and 12 months after beginning LPV/r was assessed. Sixteen (55.2%) and 19 (65.5%) of 29 patients exhibited good virological and immunological responses, respectively. Baseline CD4+ values (>500) predicted both virological and immunological responses (p<0.05). Older children were less likely to develop an immunological response (p<0.001) than younger children. Nine children receiving 3 ARV drugs plus LPV/r showed an immunological response (100%) compared to 10/20 (50%) children receiving 2 drugs plus LPV/r (p=0.01). A lower number (n<5) of infectious episodes was noted after 12 months follow-up in children using the LPV/r regimen (p=0.006). There was a positive correlation between children whose baseline CD4+ values were greater than 500 cells/mm³ and virological responses. Although virological responses to therapy were seen in about half the children (55.2%), the use of HAART containing LPV/r provided clinical and immmunological benefits.en
dc.description.affiliationFederal University of São Paulo
dc.description.affiliationSão Paulo University Faculty of Public Health
dc.description.affiliationUSP FM Institute of Tropical Medicine
dc.description.affiliationUnifespUNIFESP, EPM
dc.description.sourceSciELO
dc.format.extent16-19
dc.identifierhttp://dx.doi.org/10.1590/S1413-86702007000100006
dc.identifier.citationBrazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 11, n. 1, p. 16-19, 2007.
dc.identifier.doi10.1590/S1413-86702007000100006
dc.identifier.fileS1413-86702007000100006.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702007000100006
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/3523
dc.identifier.wosWOS:000253997600006
dc.language.isoeng
dc.publisherBrazilian Society of Infectious Diseases
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHIVen
dc.subjectChildrenen
dc.subjectHAARTen
dc.subjectlopinaviren
dc.titleFactors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonaviren
dc.typeinfo:eu-repo/semantics/article
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