Activity of mupirocin and 14 additional antibiotics against staphylococci isolated from Latin American hospitals: Report from the SENTRY Antimicrobial Surveillance Program

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dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.authorAndrade, S. S.
dc.contributor.authorSader, Helio Silva [UNIFESP]
dc.contributor.authorJones, R. N.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionJMI Labs
dc.date.accessioned2018-06-15T17:53:09Z
dc.date.available2018-06-15T17:53:09Z
dc.date.issued2004-08-01
dc.description.abstractA total of 1,346 Staphylococcus aureus (SA) and 498 coagulase-negative staphylococcal (CoNS) strains isolated from 11 Latin American medical centers between 2000 and 2001 were tested against mupirocin and other antimicrobial agents by reference broth microdilution method as part of the SENTRY Antimicrobial Surveillance Program. Oxacillin resistance (OR) was detected in 38.6% of S. aureus and in 78.1% of CoNS. The overall resistance rate to mupirocin was low among S. aureus (3.1%; MIC greater than or equal to8 mud/ml) but significantly higher among ORSA compared to oxacillin-susceptible SA (5.4% versus 1.7%; p < 0.001). Mupirocin-resistant S. aureus strains were detected in 9 of 11 centers, with individual center rates varying between 1.8 and 15.7%. Mupirocin resistance rates were high among CoNS (27.5%) and varied widely (10.0 to 48.9%) among the monitored Latin American medical centers. Mupirocin resistance rates appear to be increasing and routine monitoring for potential resistance seems prudent.en
dc.description.affiliationUniv Fed Sao Paulo, Div Infect Dis, Lab Especial Microbiol Clin, BR-04025010 Sao Paulo, Brazil
dc.description.affiliationJMI Labs, Jones Grp, North Liberty, IA USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Infect Dis, Lab Especial Microbiol Clin, BR-04025010 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent323-328
dc.identifierhttp://dx.doi.org/10.1179/joc.2004.16.4.323
dc.identifier.citationJournal Of Chemotherapy. Florence: E I F T Srl, v. 16, n. 4, p. 323-328, 2004.
dc.identifier.doi10.1179/joc.2004.16.4.323
dc.identifier.issn1120-009X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44235
dc.identifier.wosWOS:000223141700001
dc.language.isoeng
dc.publisherE I F T Srl
dc.relation.ispartofJournal Of Chemotherapy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectantimicrobial activityen
dc.subjectstaphylococcien
dc.subjectmupirocinen
dc.subjectSENTRYen
dc.titleActivity of mupirocin and 14 additional antibiotics against staphylococci isolated from Latin American hospitals: Report from the SENTRY Antimicrobial Surveillance Programen
dc.typeinfo:eu-repo/semantics/article
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