Galectin-3: A Friend but Not a Foe during Trypanosoma cruzi Experimental Infection

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dc.citation.volume7
dc.contributor.authorda Silva, Aline A.
dc.contributor.authorTeixeira, Thaise L.
dc.contributor.authorTeixeira, Samuel C.
dc.contributor.authorMachado, Fabricio C. [UNIFESP]
dc.contributor.authordos Santos, Marlus A.
dc.contributor.authorTomiosso, Tatiana C.
dc.contributor.authorTavares, Paula C. B.
dc.contributor.authore Silva Brigido, Rebecca T.
dc.contributor.authorMartins, Flavia Alves
dc.contributor.authorde Lira Silva, Nadjania S. [UNIFESP]
dc.contributor.authorRodrigues, Cassiano C.
dc.contributor.authorRoque-Barreira, Maria C.
dc.contributor.authorMortara, Renato A. [UNIFESP]
dc.contributor.authorLopes, Daiana S.
dc.contributor.authorRodrigues Avila, Veridiana de Melo
dc.contributor.authorda Silva, Claudio V.
dc.coverageLausanne
dc.date.accessioned2020-09-01T13:21:18Z
dc.date.available2020-09-01T13:21:18Z
dc.date.issued2017
dc.description.abstractTrypanosoma cruzi interacts with host cells, including cardiomyocytes, and induces the production of cytokines, chemokines, metalloproteinases, and glycan-binding proteins. Among the glycan-binding proteins is Galectin-3 (Gal-3), which is upregulated after T. cruzi infection. Gal-3 is a member of the lectin family with affinity for beta-galactose containing molecules; it can be found in both the nucleus and the cytoplasm and can be either membrane-associated or secreted. This lectin is involved in several immunoregulatory and parasite infection process. Here, we explored the consequences of Gal-3 deficiency during acute and chronic T. cruzi experimental infection. Our results demonstrated that lack of Gal-3 enhanced in vitro replication of intracellular parasites, increased in vivo systemic parasitaemia, and reduced leukocyte recruitment. Moreover, we observed decreased secretion of pro-inflammatory cytokines in spleen and heart of infected Gal-3 knockout mice. Lack of Gal-3 also led to elevated mast cell recruitment and fibrosis of heart tissue. In conclusion, galectin-3 expression plays a pivotal role in controlling T. cruzi infection, preventing heart damage and fibrosis.en
dc.description.affiliationUniv Fed Uberlandia, Inst Ciencias Biomed, Dept Imunol, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, Brazil
dc.description.affiliationUniv Fed Uberlandia, Inst Genet & Bioquim, Lab Bioquim & Toxinas Anim, Uberlandia, MG, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fcimb.2017.00463
dc.identifier.citationFrontiers In Cellular And Infection Microbiology. Lausanne, v. 7, p. -, 2017.
dc.identifier.doi10.3389/fcimb.2017.00463
dc.identifier.fileWOS000414310700001.pdf
dc.identifier.issn2235-2988
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58182
dc.identifier.wosWOS:000414310700001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Cellular And Infection Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectgalectin-3en
dc.subjectTrypanosoma cruzien
dc.subjecthearten
dc.subjectfibrosisen
dc.subjectleukocytesen
dc.titleGalectin-3: A Friend but Not a Foe during Trypanosoma cruzi Experimental Infectionen
dc.typeinfo:eu-repo/semantics/article
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