Different MOG(35-55) concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-beta in mice CNS despite unchanged clinical course

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dc.contributor.authorDias, Alyria Teixeira
dc.contributor.authorRibeiro De Castro, Sandra Bertelli
dc.contributor.authorDe Souza Alves, Caio Cesar
dc.contributor.authorMesquita, Felipe Pereira
dc.contributor.authorVisona De Figueiredo, Nathalia Stela
dc.contributor.authorEvangelista, Marcilene Gomes
dc.contributor.authorMarques Nogueira Castanon, Maria Christina
dc.contributor.authorJuliano, Maria Aparecida [UNIFESP]
dc.contributor.authorFerreira, Ana Paula
dc.contributor.institutionUniv Fed Juiz de Fora
dc.contributor.institutionFed Univ Valleys Jequitinhonha & Mucuri
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:39:58Z
dc.date.available2016-01-24T14:39:58Z
dc.date.issued2015-02-01
dc.description.abstractMultiple sclerosis (MS) shows distinct clinical courses. Experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis, can be induced by different protocols, which show distinct cytokine and antibody production. the factors involved in this heterogeneity remain unclear. the relevance of MUG concentration in triggering a regulatory response in the chronic model of EAE is imprecise. the aim of this study was investigate if 100 or 300 mu g of MOG(35-55) could induce different EAE profiles. Modifications in the concentration of MUG were able to change the patterns of chemokines, cytokines, percentage of cells, inflammatory infiltrate and the development of a regulatory response. However, these changes were unable to modify the intensity of response, which explains the chronic progression of the disease in both concentrations. the results presented in this study contribute to understanding the intricate mechanisms that trigger EAE and provide insights into the pathogenesis of various forms of MS. (C) 2015 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Juiz de Fora, Inst Biol Sci, IMUNOCET, Dept Parasitol Microbiol & Immunol, BR-36036900 Juiz de Fora, MG, Brazil
dc.description.affiliationUniv Fed Juiz de Fora, Dept Pharm, Governador Valadares, Brazil
dc.description.affiliationFed Univ Valleys Jequitinhonha & Mucuri, Fac Med, Teofilo Otoni, Brazil
dc.description.affiliationUniv Fed Juiz de Fora, Dept Morphol, BR-36036900 Juiz de Fora, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biophys, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biophys, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCNPq: 481459/2009-0
dc.description.sponsorshipIDCNPq: 303369/2009-4
dc.description.sponsorshipIDCNPq: 306575/2012-4
dc.description.sponsorshipIDCNPq: 470768/2013-4
dc.description.sponsorshipIDFAPEMIG: 02236/10
dc.description.sponsorshipIDFAPEMIG: PPM 0216/10
dc.description.sponsorshipIDFAPEMIG: 00269-14
dc.description.sponsorshipIDCAPES: PNPD-2882/2011
dc.format.extent87-94
dc.identifierhttp://dx.doi.org/10.1016/j.cellimm.2014.12.009
dc.identifier.citationCellular Immunology. San Diego: Academic Press Inc Elsevier Science, v. 293, n. 2, p. 87-94, 2015.
dc.identifier.doi10.1016/j.cellimm.2014.12.009
dc.identifier.issn0008-8749
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38688
dc.identifier.wosWOS:000350089900005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCellular Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMultiple sclerosisen
dc.subjectAnimal modelen
dc.subjectAutoimmunityen
dc.subjectMOG(35-55)en
dc.subjectCytokinesen
dc.titleDifferent MOG(35-55) concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-beta in mice CNS despite unchanged clinical courseen
dc.typeinfo:eu-repo/semantics/article
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