Evaluation of Demographic, Clinical Characteristics, and Genetic Polymorphism as Risk Factors for Pelvic Organ Prolapse in Brazilian Women

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dc.contributor.authorMartins, Karina de Falco [UNIFESP]
dc.contributor.authorKatalin de Jarmy-Di Bella, Zsuzsanna Ilona [UNIFESP]
dc.contributor.authorRodrigues Maciel da Fonseca, Andrea Moura
dc.contributor.authorCastro, Rodrigo Aquino [UNIFESP]
dc.contributor.authorCotrim Guerreiro da Silva, Ismael Dale [UNIFESP]
dc.contributor.authorBatista Castello Girao, Manoel Joao [UNIFESP]
dc.contributor.authorFerreira Sartori, Marair Gracio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2016-01-24T14:05:56Z
dc.date.available2016-01-24T14:05:56Z
dc.date.issued2011-01-01
dc.description.abstractObjective: Verify the association between genital prolapse, other risk factors and a polymorphism in exon 31 of the collagen III-a1 gene (COL3A1). Setting: the etiology of genital prolapse is multifactorial, and genetic defects have been proposed. Also, there is evidence that changes in collagen may be responsible for defects in pelvic floor support. the exon 31 polymorphism results in structural changes in the triple helical of the collagen and appears to lead to abnormal synthesis of type III collagen. Design: Basic science study. Population: the studied group consisted of 107 patients with stage III and IV genital prolapse (POP-Q). the control group included 209 women with stage 0 and I prolapse. Methods: After extracting genomic DNA from the peripheral blood, the exon 31 COL3A1 polymorphism was typed by restriction fragment length polymorphism analysis. Main outcome measures: Association between genital prolapse and exon 31 COL3A1 polymorphism. Results: No statistically significant differences in genotype and allele frequencies were found between cases and controls (P = 0.75 and 0.66, respectively). Multiple logistic regression analyses identified age (OR = 1.05; 95% CI = 1.01-1.10), BMI (OR = 1.09; 95% CI = 1.01-1.17), presence of at least one vaginal delivery (OR = 7.22; 95% CI = 1.84-28.27), positive family history of POP (OR = 2.27; 95% CI = 1.05-4.93) and a macrosomic foetus (OR = 2.91; 95% CI = 1.24-6.79) as independent risk factors for genital prolapse. in contrast, the number of caesarean deliveries was found to be an independent protective factor (OR - 0.43; 95% CI - 0.24-0.78). Conclusions: the type III collagen exon 31 polymorphism is not a risk factor for pelvic genital prolapse in this sample. Neurourol. Urodynam. 30:13251328, 2011. (C) 2011 Wiley-Liss, Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Sect Urogynecol & Pelv Surg, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Belo Horizonte, MG, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sect Urogynecol & Pelv Surg, Dept Gynecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1325-1328
dc.identifierhttp://dx.doi.org/10.1002/nau.21066
dc.identifier.citationNeurourology and Urodynamics. Malden: Wiley-Blackwell, v. 30, n. 7, p. 1325-1328, 2011.
dc.identifier.doi10.1002/nau.21066
dc.identifier.issn0733-2467
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33257
dc.identifier.wosWOS:000294727800025
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofNeurourology and Urodynamics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectgenetic polymorphismen
dc.subjectpelvic organ prolapseen
dc.subjectrisk factorsen
dc.subjecttype III collagenen
dc.titleEvaluation of Demographic, Clinical Characteristics, and Genetic Polymorphism as Risk Factors for Pelvic Organ Prolapse in Brazilian Womenen
dc.typeinfo:eu-repo/semantics/article
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