TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017)

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dc.citation.volumev. 8
dc.contributor.authorBarboza, Renato [UNIFESP]
dc.contributor.authorLima, Flavia Afonso
dc.contributor.authorReis, Aramys Silva
dc.contributor.authorMurillo, Oscar Javier
dc.contributor.authorPeixoto, Erika Paula Machado
dc.contributor.authorBandeira, Carla Leticia
dc.contributor.authorFotoran, Wesley Luzetti
dc.contributor.authorSardinha, Luis Roberto
dc.contributor.authorWunderlich, Gerhard
dc.contributor.authorBevilacqua, Estela
dc.contributor.authorD'Imperio Lima, Maria Regina
dc.contributor.authorAlvarez, Jose Maria
dc.contributor.authorMaranhao Costa, Fabio Trindade
dc.contributor.authorGoncalves, Ligia Antunes
dc.contributor.authorEpiphanio, Sabrina
dc.contributor.authorMarinho, Claudio Romero Farias
dc.coverageLondon
dc.date.accessioned2020-07-20T16:31:16Z
dc.date.available2020-07-20T16:31:16Z
dc.date.issued2018
dc.description.abstractMalaria-associate pregnancy has a signifcant impact on infant morbidity and mortality. The detrimental efects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the efect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65GFP infection model. We observed that activation of the innate immune system by parasites leads to PM due to local infammation. We identifed TLR4 activation as the main pathway involved in the infammatory process in the placental tissue since the absence of functional TLR4 in mice leads to a decrease in the pro-infammatory responses, which resulted in an improved pregnancy outcome. Additionally, a similar result was obtained when infected pregnant mice were treated with IAXO-101, a TLR4/CD14 blocker. Together, this study illustrates the importance of TLR4 signalling for the generation of the severe infammatory response involved in PM pathogenesis. Therefore, our results implicate that TLR4 blockage could be a potential candidate for therapeutic interventions to reduce malaria-induced pathology both in the mother and the fetus.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Biol, Diadema, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Biol Celular & Desenvolvimento, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Genet Evolucao & Bioagentes, Campinas, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao aulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Biol, Diadema, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-20T16:31:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2018. Added 1 bitstream(s) on 2020-07-20T17:41:31Z : No. of bitstreams: 1 WOS000426652400004a.pdf: 10532894 bytes, checksum: 04bfa25993020f0b28870c6493e4c0ad (MD5)en
dc.description.sourceWeb of Science
dc.identifierhttp://dx.doi.org/10.1038/s41598-017-08299-x
dc.identifier.citationScientific Reports. London, v. 7 2018.
dc.identifier.doi10.1038/s41598-017-08299-x
dc.identifier.fileWOS000426652400004a.pdf
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55833
dc.identifier.wosWOS:000426652400004a
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.rightsAcesso aberto
dc.titleTLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017)en
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