Estimated Rates of Retinal Ganglion Cell Loss in Glaucomatous Eyes with and without Optic Disc Hemorrhages

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dc.contributor.authorGracitelli, Carolina Pelegrini Barbosa [UNIFESP]
dc.contributor.authorTatham, Andrew J.
dc.contributor.authorZangwill, Linda M.
dc.contributor.authorWeinreb, Robert N.
dc.contributor.authorLiu, Ting
dc.contributor.authorMedeiros, Felipe A.
dc.contributor.institutionUniv Calif San Diego
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Edinburgh
dc.date.accessioned2016-01-24T14:37:44Z
dc.date.available2016-01-24T14:37:44Z
dc.date.issued2014-08-26
dc.description.abstractPurpose: To evaluate whether optic disc hemorrhages are associated with faster rates of estimated retinal ganglion cell (RGC) loss in glaucoma.Methods: A longitudinal observational cohort study of 222 eyes of 122 patients with glaucoma recruited from the Diagnostic Innovations Glaucoma Study (DIGS) followed for an average of 3.74 +/- 0.85 years. All subjects had optical coherence tomography and standard automated perimetry during follow up. Optic disc hemorrhages were detected by masked evaluation of stereophotographs. Rates of change in estimated numbers of RGCs were determined using a previously described method. A random coefficients model was used to investigate the relationship between disc hemorrhages and rates of change in estimated RGC counts over time.Results: 19 eyes of 18 subjects had at least one disc hemorrhage during follow up. At baseline, average estimated RGC counts in eyes with and without disc hemorrhages were 677,994 cells and 682,021 cells, respectively (P = 0.929). Eyes with optic disc hemorrhages during follow-up had significantly faster rates of estimated RGC loss than eyes without disc hemorrhages (22,233 cells/year versus 10,704 cells/year, P = 0.020). the effect of disc hemorrhages on the rates of estimated RGC loss remained significant after adjusting for confounding variables.Conclusion: Eyes with disc hemorrhages showed faster rates of RGC loss compared to eyes without disc hemorrhages. These results provide further evidence that disc hemorrhages should be considered as an indicator of increased risk for faster neural loss in glaucoma.en
dc.description.affiliationUniv Calif San Diego, Hamilton Glaucoma Ctr, San Diego, CA 92103 USA
dc.description.affiliationUniv Calif San Diego, Dept Ophthalmol, San Diego, CA 92103 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUniv Edinburgh, Princess Alexandra Eye Pavil, Edinburgh, Midlothian, Scotland
dc.description.affiliationUniv Edinburgh, Dept Ophthalmol, Edinburgh, Midlothian, Scotland
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health/National Eye Institute
dc.description.sponsorshipResearch to Prevent Blindness (New York, N.Y.)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAlcon
dc.description.sponsorshipAllergan
dc.description.sponsorshipPfizer
dc.description.sponsorshipMerck
dc.description.sponsorshipSanten
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY021818
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY11008
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY14267
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: EY019869
dc.description.sponsorshipIDNational Institutes of Health/National Eye Institute: P30EY022589
dc.description.sponsorshipIDCAPES: 12309-13-3
dc.format.extent8
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0105611
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 8, 8 p., 2014.
dc.identifier.doi10.1371/journal.pone.0105611
dc.identifier.fileWOS000341303200040.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38105
dc.identifier.wosWOS:000341303200040
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEstimated Rates of Retinal Ganglion Cell Loss in Glaucomatous Eyes with and without Optic Disc Hemorrhagesen
dc.typeinfo:eu-repo/semantics/article
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