Antimycobacterial activity of 2-phenoxy-1-phenylethanone, a synthetic analogue of neolignan, entrapped in polymeric microparticles

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dc.contributor.authorMinarini, Paulo R. R. [UNIFESP]
dc.contributor.authorSouza, Ana O. de
dc.contributor.authorSoares, Edson G.
dc.contributor.authorBarata, Lauro E. S.
dc.contributor.authorSilva, Celio L.
dc.contributor.authorBentley, Maria Vitoria L. B.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Butantan
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T14:26:57Z
dc.date.available2016-01-24T14:26:57Z
dc.date.issued2012-03-01
dc.description.abstractConventional treatment of tuberculosis (TB) demands a long course therapy (6 months), known to originate multiple drug resistant strains (MDR-TB), which emphasizes the urgent need for new antituberculous drugs. the purpose of this study was to investigate a novel treatment for TB meant to improve patient compliance by reducing drug dosage frequency. Polymeric microparticles containing the synthetic analogue of neolignan, 1-phenyl-2-phenoxiethanone (LS-2), were obtained by a method of emulsification and solvent evaporation and chemically characterized. Only representative LS-2-loaded microparticles were considered for further studies involving experimental murine TB induced by Mycobacterium tuberculosis H37Rv ATCC 27294. the LS-2-loaded microparticles were spherical in shape, had a smooth wall and showed an encapsulation efficiency of 93% in addition to displaying sustained release. Chemotherapeutic potential of LS-2 entrapped in microparticles was comparable to control groups. These findings are encouraging and indicate that LS-2-loaded microparticles are a potential alternative to conventional chemotherapy of TB.en
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.affiliationInst Butantan, Lab Bioquim & Biofis, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Patol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Quim, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto do Milenio REDE-TB
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 04/09465-7
dc.format.extent259-263
dc.identifierhttp://dx.doi.org/10.3109/03639045.2011.598535
dc.identifier.citationDrug Development and Industrial Pharmacy. London: Informa Healthcare, v. 38, n. 3, p. 259-263, 2012.
dc.identifier.doi10.3109/03639045.2011.598535
dc.identifier.issn0363-9045
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34699
dc.identifier.wosWOS:000299744900001
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofDrug Development and Industrial Pharmacy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectSynthetic analogue of neolignanen
dc.subject1-phenyl-2-phenoxiethanoneen
dc.subjectPLGA microparticlesen
dc.subjecttuberculosisen
dc.subjectantitubercular agenten
dc.titleAntimycobacterial activity of 2-phenoxy-1-phenylethanone, a synthetic analogue of neolignan, entrapped in polymeric microparticlesen
dc.typeinfo:eu-repo/semantics/article
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