5-HT1A receptors of the lateral septum regulate inhibitory avoidance but not escape behavior in rats

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dc.contributor.authorBarros Viana, Milena de [UNIFESP]
dc.contributor.authorZangrossi, Helio
dc.contributor.authorMassaro Onusic, Gustavo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:49:48Z
dc.date.available2016-01-24T13:49:48Z
dc.date.issued2008-05-01
dc.description.abstractSerotonin in the lateral septum (LS) has been implicated in the modulation of defensive behaviors and in anxiety. However, it is currently unknown whether changes in 5-HT mechanisms in this brain area may selectively affect defensive responses associated with specific subtypes of anxiety disorders recognized in clinical settings. To address this question, we evaluated the effect of the intra-LS injection of the 5-HT1A/7 receptor agonist 8-CH-DPAT (0.6, 3.0, 15.0 nmol) in male Wistar rats exposed to the elevated T-maze animal model of anxiety. This test allows the measurement of two behavioral defensive responses in the same rat: inhibitory avoidance and escape behavior. in clinical terms, these responses have been respectively related to generalized anxiety and panic disorder. the effects of 8-OH-DPAT were compared to those caused by a standard anxiolytic compound, the benzodiazepine receptor agonist midazolam (MDZ, 20 nmol). We also investigated whether the intra-LS injection of the 5-HT1A receptor antagonist WAY-100635 (0.37 nmol) was able to block the effects of 8-OH-DPAT. All animals were also tested in an open field for locomotor activity assessments. Results showed that whereas intra-LS administration of MDZ decreased avoidance latencies, suggesting an anxiolytic action, 8-OH-DPAT caused the opposite effect. Neither drug affected the escape performance. Intra-LS administration of WAY-100635 blocked the anxiogenic effect caused by 8-OH-DPAT. No changes to locomotion were detected in the open field. the data suggests that LS 5-HT1A receptors are involved in the control of inhibitory avoidance behavior and that a failure in this regulatory mechanism may be of importance to the physiopathology of generalized anxiety disorder. (c) 2008 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Saude, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Farmacol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, FFCLRP, Dept Psicol Educ, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Saude, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent360-366
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2008.01.007
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 89, n. 3, p. 360-366, 2008.
dc.identifier.doi10.1016/j.pbb.2008.01.007
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30645
dc.identifier.wosWOS:000255311600016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectanxietyen
dc.subjectpanicen
dc.subjectlateral septumen
dc.subject5-HT1A receptorsen
dc.subjectelevated T-mazeen
dc.title5-HT1A receptors of the lateral septum regulate inhibitory avoidance but not escape behavior in ratsen
dc.typeinfo:eu-repo/semantics/article
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