Relationship between histopathological features of chemotherapy treated retinoblastorna and P-glycoprotein expression

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dc.contributor.authorSouza, J. P.
dc.contributor.authorMartins, M. C.
dc.contributor.authorCaissie, A. L.
dc.contributor.authorTorres, VLL
dc.contributor.authorFernandes, LHCF
dc.contributor.authorErwenne, C. M.
dc.contributor.authorBurnier, M. N.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMcGill Univ
dc.date.accessioned2016-01-24T12:37:54Z
dc.date.available2016-01-24T12:37:54Z
dc.date.issued2005-06-01
dc.description.abstractBackground: P-glycoprotein (P-gp) has been identified as a possible mediator of chemoresistance in retinoblastoma. the aim of this study was to determine the expression of P-gp in retinoblastoma treated with chemotherapy prior to enucleation.Methods: Seventeen enucleated specimens of retinoblastoma from 16 patients were studied. Nine had been treated with chemotherapy alone, and eight had been treated with chemotherapy and other forms of local treatment. Tumour differentiation as well as choroidal and optic nerve invasion were assessed. P-gp immunohistochemical staining was performed and evaluated as negative, low or high.Results: Histopathological assessment of the cases showed that 14 of 17 eyes (82.3%) had viable retinoblastoma cells. Nine retinoblastomas were considered regressed with a well-differentiated component, five regressed retinoblastomas had viable cells with poor differentiation and three retinoblastomas had regressed leaving no viable cells. Sixteen of 17 retinoblastomas were P-gp positive. in the one case with optic nerve invasion and the three cases with massive choroidal invasion, P-gp expression was found in invading retinoblastoma cells.Conclusion: Almost all retinoblastomas expressed P-gp. High levels of P-gp expression might play a role in chemotherapy resistance of retinoblastoma or, conversely, chemotherapy might induce P-gp expression. These results might have an impact on management of bilateral retinoblastoma.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationMcGill Univ, Henry C Witelson Ocular Pathol Lab, Dept Ophthalmol, Montreal, PQ, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent279-284
dc.identifierhttp://dx.doi.org/10.1111/j.1442-9071.2005.00991.x
dc.identifier.citationClinical and Experimental Ophthalmology. Oxford: Blackwell Publishing, v. 33, n. 3, p. 279-284, 2005.
dc.identifier.doi10.1111/j.1442-9071.2005.00991.x
dc.identifier.issn1442-6404
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28337
dc.identifier.wosWOS:000230168600010
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofClinical and Experimental Ophthalmology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectchemotherapyen
dc.subjecthistopathologyen
dc.subjectimmunohistochemistryen
dc.subjectP-glycoproteinen
dc.subjectretinoblastomaen
dc.titleRelationship between histopathological features of chemotherapy treated retinoblastorna and P-glycoprotein expressionen
dc.typeinfo:eu-repo/semantics/article
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