Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound

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dc.citation.volume7
dc.contributor.authorMachado, Ricardo Borges [UNIFESP]
dc.contributor.authorSuchecki, Deborah [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-31T12:47:02Z
dc.date.available2020-07-31T12:47:02Z
dc.date.issued2016
dc.description.abstractSleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH (18-39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review.en
dc.description.affiliationUniv Ibirapuera, Psychosomat Res Grp, Dept Psychol, Sao Paulo, Brazil
dc.description.affiliationUniv Ibirapuera, Psychosomat Res Grp, Dept Pharm, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)/Centros de Pesquisa, Inovação e Difusão (CEPID)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP/CEPID: 98/14303-3
dc.description.sponsorshipIDCNPq: 486769/2013-5
dc.description.sponsorshipIDFAPESP: 2010/09087-3
dc.description.sponsorshipIDCNPq: 302294/2012-0
dc.description.sponsorshipIDFAPESP: 2015/26364-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fendo.2016.00163
dc.identifier.citationFrontiers In Endocrinology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fendo.2016.00163
dc.identifier.fileWOS000390233700001.pdf
dc.identifier.issn1664-2392
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56536
dc.identifier.wosWOS:000390233700001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsleepen
dc.subjectstressen
dc.subjectprolactinen
dc.subjectCLIPen
dc.subjectserotoninen
dc.subjectCRHen
dc.subjecthomeostasisen
dc.subjectREM sleepen
dc.titleNeuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebounden
dc.typeinfo:eu-repo/semantics/article
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