First report of Candida auris in America: Clinical and microbiological aspects of 18 episodes of candidemia

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dc.citation.issue4
dc.citation.volume73
dc.contributor.authorCalvo, Belinda
dc.contributor.authorMelo, Analy Salles de Azevedo [UNIFESP]
dc.contributor.authorPerozo-Mena, Armindo
dc.contributor.authorHernandez, Martin
dc.contributor.authorFrancisco, Elaine Cristina [UNIFESP]
dc.contributor.authorHagen, Ferry
dc.contributor.authorMeis, Jacques F.
dc.contributor.authorColombo, Arnaldo Lopes [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-31T12:47:43Z
dc.date.available2020-07-31T12:47:43Z
dc.date.issued2016
dc.description.abstractObjectives: Characterization of a hospital outbreak of Candida auris candidemia that involved 18 critically ill patients in Venezuela. Method: Bloodstream isolates of C. auris obtained from 18 patients admitted at a medical center in Maracaibo, between March, 2012 and July, 2013 were included. Species identification was confirmed by ITS rDNA sequencing. Isolates were subsequently typed by amplified fragment length polymorphism fingerprinting (AFLP). Susceptibility testing was performed according to CLSI. Clinical data were collected from all cases by using a standard clinical form. Results: A total of 13 critically ill pediatric and 5 adult patients, with a median age of 26 days, were included. All were previously exposed to antibiotics and multiple invasive medical procedures. Clinical management included prompt catheter removal and antifungal therapy. Thirteen patients (72%) survived up to 30 days after onset of candidemia. AFLP fingerprinting of all C. auris isolates suggested a clonal outbreak. The isolates were considered resistant to azoles, but susceptible to anidulafungin and 50% of isolates exhibited amphotericin B MIC values of >1 mu g/ml. Conclusions: The study demonstrated that C. auris is a multiresistant yeast pathogen that can be a source of health-care associated infections in tertiary care hospitals with a high potential for nosocomial horizontal transmission. (C) 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Zulia, Dept Enfermedades Infecciosas & Trop, Escuela Med, Maracaibo, Venezuela
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Lab Especial Micol, Sao Paulo, Brazil
dc.description.affiliationServ Autonomo Hosp Univ Maracaibo, Ctr Referencia Bacteriol, Maracaibo, Zulia State, Venezuela
dc.description.affiliationServ Autonomo Hosp Univ Maracaibo, Serv Med Interna, Maracaibo, Zulia State, Venezuela
dc.description.affiliationCanisius Wilhelmina Hosp CWZ, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
dc.description.affiliationRadboudumc CWZ Ctr Excellence Mycol, Nijmegen, Netherlands
dc.description.affiliationUnifespLaboratório Especial de Micologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2012/04767-1
dc.description.sponsorshipIDCNPq: 307510/2015-8
dc.description.sponsorshipIDCNPq: 150669/2014-3
dc.format.extent369-374
dc.identifierhttp://dx.doi.org/10.1016/j.jinf.2016.07.008
dc.identifier.citationJournal Of Infection. London, v. 73, n. 4, p. 369-374, 2016.
dc.identifier.doi10.1016/j.jinf.2016.07.008
dc.identifier.issn0163-4453
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57035
dc.identifier.wosWOS:000383380800007
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofJournal Of Infection
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCandida aurisen
dc.subjectCandidemiaen
dc.subjectFluconazole resistanceen
dc.subjectCandidemia outbreaken
dc.subjectAmplified fragment length polymorphismen
dc.subjectVenezuelaen
dc.titleFirst report of Candida auris in America: Clinical and microbiological aspects of 18 episodes of candidemiaen
dc.typeinfo:eu-repo/semantics/article
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