Reflex epileptic mechanisms in ictogenesis and therapeutic consequences

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dc.citation.issue5
dc.citation.volume16
dc.contributor.authorLin, Katia
dc.contributor.authorGuaranha, Mirian [UNIFESP]
dc.contributor.authorWolf, Peter
dc.coverageAbingdon
dc.date.accessioned2020-07-22T13:23:01Z
dc.date.available2020-07-22T13:23:01Z
dc.date.issued2016
dc.description.abstractRecent studies of reflex epileptic mechanisms in human epilepsy using advanced methods of neurophysiology and functional neuroimaging have contributed much to elucidate pathophysiological processes of seizure generation. Whereas in lesional focal epilepsies reflex mechanisms usually relate directly to the anatomical focus, in system epilepsies they have helped to define which functional anatomical systems serving physiological function are recruited by the ictogenic mechanisms. Reflex epileptic seizures can often be prevented by avoidance or modification of triggers or by prophylactic benzodiazepine administration. Surgical options apply to focal cases. According to restricted experiences with pharmacotherapy, without controlled studies and little information on new AEDs, reflex seizures in system epilepsies appear to respond best to valproic acid and in focal epilepsies, to carbamazepine.en
dc.description.affiliationUniv Fed Santa Catarina, Univ Hosp, Dept Clin Med, Serv Neurol, Florianopolis, SC, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Hosp Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationDanish Epilepsy Ctr, Kolonivej 2, DK-4293 Dianalund, Denmark
dc.description.affiliationUnifespUniv Fed Sao Paulo, Hosp Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq (Brazilian Council for Scientific and Technologic Development, Brazil) PQ2 Research Fellowship
dc.description.sponsorshipCAPES
dc.description.sponsorshipIDCNPq: 307861/2013-9
dc.description.sponsorshipIDCAPES: 88,881.030478/2013-01
dc.format.extent573-585
dc.identifierhttp://dx.doi.org/10.1586/14737175.2016.1169174
dc.identifier.citationExpert Review Of Neurotherapeutics. Abingdon, v. 16, n. 5, p. 573-585, 2016.
dc.identifier.doi10.1586/14737175.2016.1169174
dc.identifier.issn1473-7175
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55989
dc.identifier.wosWOS:000374950900012
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofExpert Review Of Neurotherapeutics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectReflex seizuresen
dc.subjectsystem epilepsiesen
dc.subjectictogenesisen
dc.subjectepileptic networksen
dc.subjectnon-pharmacological epilepsy treatmenten
dc.subjectepilepsy treatment strategiesen
dc.titleReflex epileptic mechanisms in ictogenesis and therapeutic consequencesen
dc.typeinfo:eu-repo/semantics/article
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