Inter- and intraobserver reproducibility of thyroid fine needle aspiration cytology: an analysis of discrepant cases

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dc.contributor.authorGerhard, R.
dc.contributor.authorCunha Santos, G. da
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:42:04Z
dc.date.available2016-01-24T12:42:04Z
dc.date.issued2007-04-01
dc.description.abstractObjective: To determine the inter- and intraobserver reproducibility and analyse the discrepant cases of fine needle aspiration cytology (FNAC) of the thyroid.Methods: Cases of thyroid FNAC with a corresponding histological diagnosis were reviewed regarding the original cytological diagnoses by two observers. the final cytological diagnoses (FCD) included both concordant and consensus diagnoses. the inter- and intraobserver reproducibility and efficacy of thyroid FNAC were calculated based on the FCD.Results: A total of 97 FNAC cases with corresponding histopathological specimens were analysed. Although inter- and intraobserver disagreement in the cytological diagnoses occurred in about one-quarter of the cases analysed (24.7% and 23.7%, respectively), a substantial level of diagnostic interobserver (kappa = 0.71) and intraobserver (kappa = 0.66) reproducibility was observed. the efficacy of the method was 94.4%. Disagreement in the diagnosis was detected in 24 cases (24.7%), most of them (41.7%) for follicular lesions. Discordant cytological diagnoses between the two observers were represented by six (16.2%) of the 37 cases with an FCD of colloid nodule, five (41.7%) of the 12 cases of cellular follicular lesion, all three cases of follicular neoplasm, in two (6.3%) of the 32 cases of PTC, one (16.7%) of six cases of follicular neoplasm with a predominance of Hurthle cells and in one case of poorly differentiated neoplasia. Similarly, major disagreement in intraobserver cytological diagnoses was observed for the diagnosis of follicular lesions: 18 (78.3%) of a total of 23 discordant cases.Conclusion: As discrepancies in the cytopathological diagnosis can have repercussions in the management of patients, all cases with a cytological diagnosis of follicular lesions/neoplams should be reviewed in multidisciplinary meetings thus minimizing interobserver variability.en
dc.description.affiliationUniv São Paulo, Fac Med, Hosp Clin, Dept Pathol,Div Anat Patol, BR-05403000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent105-111
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2303.2006.00430.x
dc.identifier.citationCytopathology. Oxford: Blackwell Publishing, v. 18, n. 2, p. 105-111, 2007.
dc.identifier.doi10.1111/j.1365-2303.2006.00430.x
dc.identifier.issn0956-5507
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29646
dc.identifier.wosWOS:000245252400006
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofCytopathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectthyroid lesionsen
dc.subjectfine needle aspiration cytologyen
dc.subjectdiagnostic efficacyen
dc.subjectdiagnostic reproducibilityen
dc.titleInter- and intraobserver reproducibility of thyroid fine needle aspiration cytology: an analysis of discrepant casesen
dc.typeinfo:eu-repo/semantics/article
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