Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women

Página do item simplificado
dc.contributor.authorWaitzberg, Dan Linetzky
dc.contributor.authorPereira, Claudia Cristina Alves [UNIFESP]
dc.contributor.authorLogullo, Luciana da Costa Eduardo
dc.contributor.authorJacintho, Thiago Manzoni
dc.contributor.authorAlmeida, Danielle Fontes de
dc.contributor.authorSilva, Maria de Lourdes Teixeira da
dc.contributor.authorTorrinhas, Raquel Susana Matos de Miranda
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionGANEP Nutr Humana
dc.date.accessioned2016-01-24T14:17:39Z
dc.date.available2016-01-24T14:17:39Z
dc.date.issued2012-01-01
dc.description.abstractIntroduction: Prebiotics positively affect gut microbiota composition, thus improving gut function. These properties may be useful for the treatment of constipation.Objectives: This study assessed the tolerance and effectiveness of a prebiotic inulin/partially hydrolyzed guar gum mixture (I-PHGG) for the treatment of constipation in females, as well as its influence on the composition of intestinal microbiota and production of short chain fatty acids.Methods: Our study enrolled 60 constipated female health worker volunteers. Participants reported less than 3 bowel movements per week. Volunteers were randomized to treatment with prebiotic or placebo. Treatment consisted of 3 weeks supplementation with 15 g/d I-PHGG (fiber group) or maltodextrin (placebo group). Abdominal discomfort, flatulence, stool consistency, and bowel movements were evaluated by a recorded daily questionnaire and a weekly interview. Changes in fecal bacterial population and short chain fatty acids were assessed by real-time PCR and gas chromatography, respectively.Results: There was an increased frequency of weekly bowel movements and patient satisfaction in both the fiber and placebo groups with no significant differences. Total Clostridium sp significantly decreased in the fiber group (p = 0.046) and increased in the placebo group (p = 0.047). There were no changes in fecal short chain fatty acid profile.Conclusions: Consumption of I-PHGG produced clinical results comparable to placebo in constipated females, but had additional protective effects on gut rnicrobiota by decreasing the amount of pathological bacteria of the Clostridium genera.en
dc.description.affiliationUniv São Paulo, Fac Med, Sch Med, Dept Gastroenterol,Surg Gastroenterol Discipline, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociences, Santos, Brazil
dc.description.affiliationGANEP Nutr Humana, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosciences, Santos, Brazil
dc.description.provenanceMade available in DSpace on 2016-01-24T14:17:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-01-01. Added 1 bitstream(s) on 2016-01-31T13:35:36Z : No. of bitstreams: 1 WOS000300036300014.pdf: 102687 bytes, checksum: 8c7c2b91a78381f2141382e10aeb27c2 (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 07/58600-2
dc.format.extent123-129
dc.identifierhttps://scielo.isciii.es/pdf/nh/v27n1/14_original_03.pdf
dc.identifier.citationNutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 27, n. 1, p. 123-129, 2012.
dc.identifier.doi10.3305/nh.2012.27.1.5445
dc.identifier.fileWOS000300036300014.pdf
dc.identifier.issn0212-1611
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/34397
dc.identifier.wosWOS:000300036300014
dc.language.isoeng
dc.publisherAula Medica Ediciones
dc.relation.ispartofNutricion Hospitalaria
dc.rightsAcesso aberto
dc.subjectGuar gumen
dc.subjectInulinen
dc.subjectGut microbiotaen
dc.subjectShort-chain fatty acidsen
dc.subjectConstipationen
dc.titleMicrobiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated womenen
dc.title.alternativeBeneficios en la microbiota intestinal después de la suplementación con inulina y la goma guar parcialmente hidrolizada: un ensayo clínico aleatorizado en mujeres con estreñimientoes
dc.typeArtigo
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000300036300014.pdf
Tamanho:
100.28 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
ISS - Artigos