Cognitive decline in temporal lobe epilepsy due to unilateral hippocampal sclerosis

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dc.contributor.authorMarques, Carolina Mattos
dc.contributor.authorSales Ferreira Caboclo, Luis Otavio
dc.contributor.authorSilva, Tatiana Indelicato da
dc.contributor.authorSilva Noffs, Maria Helena da
dc.contributor.authorCarrete, Henrique
dc.contributor.authorLin, Katia
dc.contributor.authorLin, Jaime
dc.contributor.authorSakamoto, Americo Ceiki
dc.contributor.authorTargas Yacubian, Elza Marcia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:48:40Z
dc.date.available2016-01-24T13:48:40Z
dc.date.issued2007-05-01
dc.description.abstractObjective. We assessed the cognitive performance of patients with temporal lobe epilepsy (TLE) caused by unilateral hippocampal sclerosis (HS), in comparison with that of matched, healthy controls. We report the relationship between cognitive measures and duration of epilepsy, correlating with hippocampal volumes, and the impact of educational level on cognitive decline.Methods. This study involved 61 outpatients (40 with <= 8 years and 21 with >8 years of formal education) with unilateral HS and 61 controls. Volumetric MRI was performed on all patients and 10 controls. the results (mean, SD) of the neuropsychological tests of healthy subjects and patients were compared using the Student t and Mann-Whitney tests.Results. Patients performed worse than controls in the neuropsychological evaluation. When adjusted z scores were used to calculate the impairment index, patients had a greater percentage of abnormal tests compared with controls. the cognitive decline, assessed through the impairment index, correlated with duration of epilepsy. Higher level of education did not protect against this decline, thus not supporting the hypothesis of cerebral reserve in this population. A significant correlation between hippocampal volumetric measures and duration of epilepsy was observed only in patients with left HS.Conclusion. Patients with TLE caused by HS present with cognitive morbidity that extends beyond memory deficits. Cognitive decline is associated with duration of epilepsy, and in patients with left-sided HS, duration may correlate with volumetric hippocampal loss. (C) 2007 Elsevier Inc. All rights reserved.en
dc.description.affiliationEscola Paulista Med, UNIFESP, Dept Neurol, São Paulo, Brazil
dc.description.affiliationEscola Paulista Med, UNIFESP, Dept Radiol, São Paulo, Brazil
dc.description.affiliationUnifespEscola Paulista Med, UNIFESP, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifespEscola Paulista Med, UNIFESP, Dept Radiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent477-485
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2007.02.002
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 10, n. 3, p. 477-485, 2007.
dc.identifier.doi10.1016/j.yebeh.2007.02.002
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29717
dc.identifier.wosWOS:000246322200020
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjecttemporal lobe epilepsyen
dc.subjectneuropsychological evaluationen
dc.subjectcognitive declineen
dc.subjectMRI volumetric measuresen
dc.titleCognitive decline in temporal lobe epilepsy due to unilateral hippocampal sclerosisen
dc.typeinfo:eu-repo/semantics/article
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