Genetically altered animal models in the kallikrein-kinin system

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dc.contributor.authorPesquero, J. B.
dc.contributor.authorBader, M.
dc.contributor.institutionMax Delbruck Ctr Mol Med
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:40:59Z
dc.date.available2016-01-24T12:40:59Z
dc.date.issued2006-02-01
dc.description.abstractTransgenic and gene-targeting technologies allowing the generation of genetically altered animal models have greatly advanced our understanding of the function of specific genes. This is also true for the kallikrein-kinin system (KKS), in which some, but not yet all, components have been functionally characterized using such techniques. the first genetically altered animal model for a KKS component was supplied by nature, the brown Norway rat carrying an inactivating mutation in the kininogen gene. Mice deficient in tissue kallikrein, B1 and B2 receptors, some kinin-degrading enzymes, and factor XII followed, together with transgenic rat and mouse strains overexpressing tissue kallikrein, B1 and B2 receptors, and degrading enzymes. There are still no animal models with genetic alterations in plasma kallikrein, kininases I and some other degrading enzymes. the models have confirmed an important role of the KKS in cardiovascular pathology, inflammation, and pain, and have partially elucidated the distinct function of the two receptors. This created the basis for rational decisions concerning the putative use of kinin receptor agonists and antagonists in therapeutic applications. However, a more thorough analysis of the existing models and the generation of new, more sophisticated transgenic models will be necessary to clarify the still elusive issue as to where and by which mechanisms the kinins exert their actions.en
dc.description.affiliationMax Delbruck Ctr Mol Med, D-13125 Berlin, Germany
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent119-126
dc.identifierhttp://dx.doi.org/10.1515/BC.2006.017
dc.identifier.citationBiological Chemistry. Berlin: Walter de Gruyter & Co, v. 387, n. 2, p. 119-126, 2006.
dc.identifier.doi10.1515/BC.2006.017
dc.identifier.issn1431-6730
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28742
dc.identifier.wosWOS:000235777400002
dc.language.isoeng
dc.publisherWalter de Gruyter & Co
dc.relation.ispartofBiological Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectbradykininen
dc.subjectkininaseen
dc.subjectkininogenen
dc.subjectkinin receptoren
dc.subjectknockout animalsen
dc.subjecttransgenic animalsen
dc.titleGenetically altered animal models in the kallikrein-kinin systemen
dc.typeinfo:eu-repo/semantics/article
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