Silver nanoparticles: a brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticles

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dc.contributor.authorLima, Renata de
dc.contributor.authorSeabra, Amedea B. [UNIFESP]
dc.contributor.authorDuran, Nelson
dc.contributor.institutionUniv Sorocaba
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T14:27:56Z
dc.date.available2016-01-24T14:27:56Z
dc.date.issued2012-11-01
dc.description.abstractIn recent years interest in silver nanoparticles and their applications has increased mainly because of the important antimicrobial activities of these nanomaterials, allowing their use in several industrial sectors. However, together with these applications, there is increasing concerning related to the biological impacts of the use of silver nanoparticles on a large scale, and the possible risks to the environment and health. in this scenario, some recent studies have been published based on the investigation of potential inflammatory effects and diverse cellular impacts of silver nanoparticles. Another important issue related to nanoparticle toxicity in biological media is the capacity for increased damage to the genetic material, since nanoparticles are able to cross cell membranes and reach the cellular nucleus. in this regard, there is increasing interest in the analysis of potential nanoparticle genotoxicity, including the effects of different nanoparticle sizes and methods of synthesis. However, little is known about the genotoxicity of different silver nanoparticles and their effects on the DNA of organisms; thus further studies in this field are required. This mini-review aims to present and to discuss recent publications related to genotoxicity and the cytotoxicity of silver nanoparticles in order to better understand the possible applications of these nanomaterials in a safe manner. This present work concludes that biogenic silver nanoparticles are generally less cyto/genotoxic in vivo compared with chemically synthesized nanoparticles. Furthermore, human cells were found to have a greater resistance to the toxic effects of silver nanoparticles in comparison with other organisms. Copyright (c) 2012 John Wiley & Sons, Ltd.en
dc.description.affiliationUniv Sorocaba, Dept Biotechnol, BR-18023000 Sorocaba, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, UFSCar, Sorocaba, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Exact & Earth Sci Dept, Diadema, SP, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Nat & Human Sci, Santo Andre, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Chem, Biol Chem Lab, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Exact & Earth Sci Dept, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent867-879
dc.identifierhttp://dx.doi.org/10.1002/jat.2780
dc.identifier.citationJournal of Applied Toxicology. Hoboken: Wiley-Blackwell, v. 32, n. 11, p. 867-879, 2012.
dc.identifier.doi10.1002/jat.2780
dc.identifier.issn0260-437X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35444
dc.identifier.wosWOS:000309190200001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Applied Toxicology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectnanotoxicologyen
dc.subjectsilver nanoparticleen
dc.subjectgenotoxicityen
dc.subjectnanotechnologyen
dc.subjectnanobiotechnologyen
dc.subjectbiogenic nanoparticleen
dc.subjectcytotoxicityen
dc.titleSilver nanoparticles: a brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticlesen
dc.typeinfo:eu-repo/semantics/article
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