Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa

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dc.contributor.authorBalsalobre, Leonardo [UNIFESP]
dc.contributor.authorPezato, Rogerio [UNIFESP]
dc.contributor.authorPerez-Novo, Claudina
dc.contributor.authorAlves, Maria Teresa S. [UNIFESP]
dc.contributor.authorSantos, Rodrigo P. [UNIFESP]
dc.contributor.authorBachert, Claus
dc.contributor.authorWeckx, Luc L. M. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Ghent
dc.date.accessioned2016-01-24T14:31:35Z
dc.date.available2016-01-24T14:31:35Z
dc.date.issued2013-04-15
dc.description.abstractObjective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, São Paulo, Brazil
dc.description.affiliationUniv Ghent, Ghent Univ Hosp, Dept Otorhinolaryngol, Upper Airway Res Lab, B-9000 Ghent, Belgium
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent5
dc.identifierhttp://dx.doi.org/10.1186/1916-0216-42-29
dc.identifier.citationJournal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
dc.identifier.doi10.1186/1916-0216-42-29
dc.identifier.fileWOS000318410400001.pdf
dc.identifier.issn1916-0216
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36209
dc.identifier.wosWOS:000318410400001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofJournal of Otolaryngology-head & Neck Surgery
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTGF-beta 1en
dc.subjectNasal polypsen
dc.subjectRhinosinusitisen
dc.subjectMucosaen
dc.titleEpithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosaen
dc.typeinfo:eu-repo/semantics/article
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