Endovascular model of abdominal aortic aneurysm induction in swine

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dc.contributor.authorLederman, Alex
dc.contributor.authorSaliture Neto, Fernando Tavares
dc.contributor.authorFerreira, Rimarcs [UNIFESP]
dc.contributor.authorFigueiredo, Luis Francisco Poli de
dc.contributor.authorOtoch, Jose Pinhata
dc.contributor.authorAun, Ricardo
dc.contributor.authorSilva, Erasmo Simao da
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:20Z
dc.date.available2016-01-24T14:37:20Z
dc.date.issued2014-06-01
dc.description.abstractAbdominal aortic aneurysms are among the main causes of death. the high morbidity and mortality associated with aneurysm rupture and repair represents a challenge for surgeons and high risk for patients. Although experimental models are useful to understand, train, and develop new treatment and diagnostic methods for this pathology, animal models developed to date are far from ideal. Animals are either too small and do not represent the pathology of humans, or the procedures employ laparotomy, or the aortic behavior does not resemble that of a true aneurysm. We developed a novel, less invasive and effective method to induce true aortic aneurysms in Large White pigs. Animals were submitted to an endovascular chemical induction using either calcium chloride (25%) or swine pancreatic elastase. Controls were exposed to saline solution. All animals were operated on using the same surgical technique under general anesthesia. They were followed weekly with ultrasound examinations and at 4 weeks the aorta was harvested. Although elastase induced only arterial dilation, imaging, histological, and biomechanical studies of the aorta revealed the formation of true aneurysms in animals exposed to calcium chloride. Aneurysms in the latter group had biomechanical failure properties similar to those of human aneurysms. These findings indicate that the endovascular approach is viable and does not cause retroperitoneal fibrosis.en
dc.description.affiliationUniv São Paulo, Univ Hosp, São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2010/07307-6
dc.format.extent167-174
dc.identifierhttp://dx.doi.org/10.1177/1358863X14534006
dc.identifier.citationVascular Medicine. London: Sage Publications Ltd, v. 19, n. 3, p. 167-174, 2014.
dc.identifier.doi10.1177/1358863X14534006
dc.identifier.issn1358-863X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37803
dc.identifier.wosWOS:000337579800002
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofVascular Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectaortic aneurysmen
dc.subjectbiomechanicsen
dc.subjectcalcium chlorideen
dc.subjectelastaseen
dc.subjectpig modelen
dc.titleEndovascular model of abdominal aortic aneurysm induction in swineen
dc.typeinfo:eu-repo/semantics/article
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