Validity of the Portuguese CHO-KLAT in Brazil

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dc.citation.issue6
dc.citation.volume22
dc.contributor.authorVillaca, Paula Ribeiro
dc.contributor.authorBlanchette, V. S.
dc.contributor.authorCarneiro, J. D. A.
dc.contributor.authorOzelo, Margareth Castro
dc.contributor.authorAntunes, Sandra Vallin [UNIFESP]
dc.contributor.authorFeldman, B. M.
dc.contributor.authorAbad, A.
dc.contributor.authorUsuba, K.
dc.contributor.authorYoung, N. L.
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:26Z
dc.date.available2020-07-31T12:47:26Z
dc.date.issued2016
dc.description.abstractIntroductionIt is essential to assess the health-related quality of life outcomes of boys with haemophilia in Brazil. The Canadian Haemophilia Outcomes-Kids Life Assessment Tool (CHO-KLAT) was recently adapted for this population. AimTo test the construct validity of the Portuguese version of the CHO-KLAT. MethodsWe recruited 50 boys, with moderate [factor VIII (FVIII) level 1-5%] or severe (FVIII level <1%) haemophilia, to participate in a descriptive study to establish a baseline understanding of the current status of boys with haemophilia in Brazil. All boys were required to complete the Brazilian CHO-KLAT and Brazilian Pediatric Quality of Life Inventory (PedsQL) by self-report. We examined the correlation between the CHO-KLAT and PedsQL scores to establish the construct validity of the Brazilian version of the CHO-KLAT. ResultsWe obtained CHO-KLAT and PedsQL data from 35 boys with severe haemophilia and 15 with moderate haemophilia. They ranged in age from 7.3 to 18.0 years, with a mean of 13.0 years. They reported a mean CHO-KLAT score of 72.3 (range = 44.1-93.9). The mean PedsQL score was 79.9 (range = 45.7-96.7), with physical health (mean of 83.9) being better than psychosocial health (77.8). The Pearson's correlation between CHO-KLAT and PedsQL was 0.47 respectively (P < 0.001). The CHO-KLAT had a moderate and inverse relationship with the degree to which they were bothered by their haemophilia ( = -0.53), while the PedsQL had a weaker relationship ( = -0.27). ConclusionThe results confirm the validity of the Portuguese version of the CHO-KLAT. This measure is now available for clinical trials in boys with haemophilia in Brazil.en
dc.description.affiliationUniv Sao Paulo, Hosp Clin, Serv Hematol, Fac Med, Sao Paulo, Brazil
dc.description.affiliationHosp Sick Children, Div Hematol Oncol, Toronto, ON, Canada
dc.description.affiliationUniv Sao Paulo, Ctr Hemofilia, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med, Hosp Clin, Inst Crianca, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, INCT Sangue, Hemoctr Unicamp, Claudio LP Correa,Unit Hemophilia, Campinas, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Hematol, Sao Paulo, Brazil
dc.description.affiliationHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
dc.description.affiliationHosp Sick Children, Child Hlth Evaluat Sci, Toronto, ON, Canada
dc.description.affiliationLaurentian Univ, Evaluating Childrens Hlth Outcomes Res Ctr, Sudbury, ON, Canada
dc.description.affiliationLaurentian Univ, Sch Rural & No Hlth, Sudbury, ON, Canada
dc.description.affiliationUnifespDepartment of Hematology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-31T12:47:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.description.sourceWeb of Science
dc.description.sponsorshipBaxalta US Inc. Corporation through Baxalta Grants competition
dc.format.extent894-897
dc.identifierhttp://dx.doi.org/10.1111/hae.13031
dc.identifier.citationHaemophilia. Hoboken, v. 22, n. 6, p. 894-897, 2016.
dc.identifier.doi10.1111/hae.13031
dc.identifier.issn1351-8216
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56829
dc.identifier.wosWOS:000388493000027
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofHaemophilia
dc.rightsAcesso restrito
dc.subjecthaemophiliaen
dc.subjectoutcome measurementen
dc.subjectpaediatricsen
dc.subjectquality of lifeen
dc.titleValidity of the Portuguese CHO-KLAT in Brazilen
dc.typeArtigo
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