The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study

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dc.citation.issue4
dc.citation.volume12
dc.contributor.authorHernandes, Fabiana Rodrigues [UNIFESP]
dc.contributor.authorFernandes Canziani, Maria Eugenia [UNIFESP]
dc.contributor.authorBarreto, Fellype Carvalho [UNIFESP]
dc.contributor.authorSantos, Rodrigo Oliveira [UNIFESP]
dc.contributor.authorMoreira, Valeria de Melo
dc.contributor.authorRochitte, Carlos Eduardo
dc.contributor.authorCarvalho, Aluizio Barbosa
dc.coverageSan Francisco
dc.date.accessioned2020-07-17T14:02:17Z
dc.date.available2020-07-17T14:02:17Z
dc.date.issued2017
dc.description.abstractParathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction of bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed to prospectively investigate the impact of PTX on bone remodeling and its potential consequence on the progression of VC in hemodialysis patients. In this prospective study, 19 hemodialysis patients with severe secondary hyperparathyroidism (sHPT) were evaluated. All patients underwent laboratorial tests and coronary tomography at baseline and, 6 and 12 months after PTXen
dc.description.abstractbone biopsy was performed at baseline and 12-month. At baseline, all patients had increased PTH levels up to 2500 pg/mL and high turnover bone disease in their bone biopsies. Fourteen (74%) patients had VC. During the follow-up, there was a significant decrease of PTH at 6 and 12-month. At 12-month, 90% of the patients evolved to low turnover bone disease. During the period of the hungry bone syndrome (first 6 months), no change of coronary calcium score was observed. However, calcium score increased significantly thereafter (12(th) month). There was an association between VC progression and the severity of low turnover bone disease. In conclusion, the shift from high to low turnover bone disease after PTX occurs in parallel to VC progression, contributing to the understanding of the complex pathophysiology involving mineral metabolism and cardiovascular disease in hemodialysis patients.en
dc.description.affiliationUniv Fed Sao Paulo, Nephrol Div, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Parana, Nephrol Div, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Head & Neck Surg Div, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Cardiol Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Nephrol Div, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (CNPq)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0174811
dc.identifier.citationPlos One. San Francisco, v. 12, n. 4, p. -, 2017.
dc.identifier.doi10.1371/journal.pone.0174811
dc.identifier.fileWOS000399371900040.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54724
dc.identifier.wosWOS:000399371900040
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up studyen
dc.typeinfo:eu-repo/semantics/article
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