The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data

Página do item simplificado
dc.citation.issue2
dc.citation.volume39
dc.contributor.authorGouvea, Eduardo S. [UNIFESP]
dc.contributor.authorSantos Filho, Airton F. [UNIFESP]
dc.contributor.authorOta, Vanessa K. [UNIFESP]
dc.contributor.authorMrad, Vinicius [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorBressan, Rodrigo A. [UNIFESP]
dc.contributor.authorCordeiro, Quirino [UNIFESP]
dc.contributor.authorBelangero, Sintia I. [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:02:24Z
dc.date.available2020-07-17T14:02:24Z
dc.date.issued2017
dc.description.abstractObjective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (and its subphenotypes) and polymorphisms in the CNR1 gene, which encodes cannabinoid receptors classically implicated in schizophrenia pathophysiology, as well as to present unpublished results of an association study in a Brazilian population. Methods: Two reviewers independently searched for eligible studies and extracted outcome data using a structured form. Papers were retrieved from PubMed and ISI Web of Knowledge using the search term schizophrenia in combination with CNR1 or CB1 or cannabinoid receptor. Twenty-four articles met our inclusion criteria. We additionally present data from a study of our own comparing 182 patients with schizophrenia and 244 healthy controls. Results: No consistent evidence is demonstrated. Conclusion: Some seemingly positive association studies stress the need for further investigations of the possible role of endocannabinoid genetics in schizophrenia.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Lab Interdisciplinar Neurociencias Clin LiNC, Sao Paulo, SP, Brazil
dc.description.affiliationIrmandade Santa Casa Misericordia Sao Paulo, Dept Psiquiatria, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Morfol & Genet, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Interdisciplinar Neurociencias Clin LiNC, Sao Paulo, SP, Brazi
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP) [2010/08968-6, 2011/50740-5, 2011/00030-1]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCNPq
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao Safra
dc.description.sponsorshipFundacao ABADS
dc.format.extent160-171
dc.identifierhttp://dx.doi.org/10.1590/1516-4446-2016-1969
dc.identifier.citationRevista Brasileira De Psiquiatria. Sao Paulo, v. 39, n. 2, p. 160-171, 2017.
dc.identifier.doi10.1590/1516-4446-2016-1969
dc.identifier.fileS1516-44462017000200160.pdf
dc.identifier.issn1516-4446
dc.identifier.scieloS1516-44462017000200160
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54787
dc.identifier.wosWOS:000403273400013
dc.language.isoeng
dc.publisherAssoc Brasileira Psiquiatria
dc.relation.ispartofRevista Brasileira De Psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCannabinoid receptorsen
dc.subjectcannabinoid receptors type-1en
dc.subjectgeneen
dc.subjectassociation studiesen
dc.titleThe role of the CNR1 gene in schizophrenia: a systematic review including unpublished dataen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1516-44462017000200160.pdf
Tamanho:
446.15 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos