Strategies for the management of ohss: results from freezing-all cycles

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dc.contributor.authorBorges Junior, Edson
dc.contributor.authorBraga, Daniela Paes Almeida Ferreira [UNIFESP]
dc.contributor.authorSetti, Amanda Souza
dc.contributor.authorVingris, Livia S.
dc.contributor.authorFigueira, Rita Cássia Savio
dc.contributor.authorIaconelli Junior, Assumpto
dc.date.accessioned2019-01-21T10:29:28Z
dc.date.available2019-01-21T10:29:28Z
dc.date.issued2016
dc.description.abstractObjective: To compare the use of GnRH agonist (GnRHa) or hCG trigger in potential OHSS patients undergoing freeze-all programs. We also compared the clinical outcomes when fresh versus freeze-thawed embryo transfers were performed in cycles with a high number of retrieved oocytes. Methods: The study included potential OHSS patients who received GnRHa (n= 74) or hCG (n= 49) trigger. The protocols were compared with respect to the clinical outcomes. We also compared the clinical outcomes of cycles in which hCG trigger was used and more than 20 MII oocytes were retrieved when: fresh embryo transfer protocol (n= 153) or freeze-all protocol (n= 123) were performed. Results: A decreased serum estradiol level, a decreased number of retrieved oocytes, an increased MII retrieved rate, and decreased fertilization rate was observed in the hCG when compared with the GnRHa group. No significant differences were noted concerning clinical outcomes. When fresh cycles were compared with frozen-thawed cycles, the estradiol serum level and the number of cryopreserved embryos were higher in the frozen-thawed cycles. The clinical pregnancy rate was higher among freeze-all cycles, as well as the implantation and cumulative pregnancy rates, when compared with fresh embryo transfer cycles. Conclusion: The use of GnRHa trigger may be a good alternative to prevent the OHSS in patients presenting an extreme ovarian response to COS, leading to similar clinical outcomes, when compared with the traditional hCG trigger. Moreover, our findings demonstrated that the strategy of freezing-all embryos not only decreases the risk of OHSS but also leads to a better pregnancy rate.en
dc.description.affiliationFertility – Medical Group - Sao Paulo – Brazil
dc.description.affiliation[Borges, Edson, Jr.
dc.description.affiliationSapientiae Institute – Centro de Estudos e Pesquisa em Reprodução Assistida
dc.description.affiliationDisciplina de Urologia, Área de Reprodução Humana, Departamento de Cirurgia, Universidade Federal de São Paulo
dc.description.affiliationUnifespDisciplina de Urologia, Área de Reprodução Humana, Departamento de Cirurgia, Universidade Federal de São Paulo
dc.description.sourceWeb of Science
dc.format.extent8-12
dc.identifierhttp://dx.doi.org/10.5935/1518-0557.20160003
dc.identifier.citationJornal Brasileiro De Reproducao Assistida. Ribeirao, v. 20, n. 1, p. 8-12, 2016.
dc.identifier.doi10.5935/1518-0557.20160003
dc.identifier.issn1517-5693
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49232
dc.identifier.wosWOS:000405249100003
dc.language.isoeng
dc.publisherRevista De Saude Publica
dc.relation.ispartofJornal Brasileiro De Reproducao Assistida
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOhssen
dc.subjectFreezingen
dc.subjectThawingen
dc.subjectHcgen
dc.subjectGnrhaen
dc.subjectTriggerOvarian Hyperstimulation Syndromeen
dc.subjectFinal Oocyte Maturationen
dc.subjectIn-Vitro Fertilizationen
dc.subjectLow-Dose Hcgen
dc.subjectGnrh Agonisten
dc.subjectEmbryo-Transferen
dc.subjectInjectionen
dc.subjectFreshen
dc.subjectCombinationen
dc.subjectPreventionen
dc.titleStrategies for the management of ohss: results from freezing-all cyclesen
dc.typeinfo:eu-repo/semantics/article
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