Cross-priming of long lived protective CD8(+) T cells against Trypanosoma cruzi infection: Importance of a TLR9 agonist and CD4(+) T cells

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dc.contributor.authorAlencar, Bruna C. G. de
dc.contributor.authorAraujo, Adriano F. S.
dc.contributor.authorPenido, Marcus L. O.
dc.contributor.authorGazzinelli, Ricardo T.
dc.contributor.authorRodrigues, Mauricio M.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFiocruz MS
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2016-01-24T13:48:59Z
dc.date.available2016-01-24T13:48:59Z
dc.date.issued2007-08-10
dc.description.abstractWe recently described that vaccination of mice with a gluthatione S transferase fusion protein representing amino acids 261-500 of the Amastigote Surface Protein-2 efficiently cross-primed protective CD8(+) T cells against a lethal challenge with the human protozoan parasite Trypanosoma cruzi. in this study, we initially established that this protective immunity was long lived. Subsequently, we studied the importance of TLR9 agonist CpG ODN 1826, TLR4 and CD4(+) T cells for the generation of these protective CD8(+) T cells. We found that: (i) the TLR9 agonist CpG ODN 1826 improved the efficiency of protective immunity; (ii) TLR4 is not relevant for priming of specific CD8(+) T cells; (iii) CD4(+) T cells are critical for priming of memory/protective CD8(+) T cells. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, CINTERGEN, BR-04044010 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04044010 São Paulo, Brazil
dc.description.affiliationFiocruz MS, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Minas Gerais, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, CINTERGEN, BR-04044010 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04044010 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent6018-6027
dc.identifierhttp://dx.doi.org/10.1016/j.vaccine.2007.05.022
dc.identifier.citationVaccine. Oxford: Elsevier B.V., v. 25, n. 32, p. 6018-6027, 2007.
dc.identifier.doi10.1016/j.vaccine.2007.05.022
dc.identifier.issn0264-410X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29956
dc.identifier.wosWOS:000248905800008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofVaccine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectvaccinationen
dc.subjectTrypanosoma cruzien
dc.subjectamastigotesen
dc.subjectCpG ODNen
dc.titleCross-priming of long lived protective CD8(+) T cells against Trypanosoma cruzi infection: Importance of a TLR9 agonist and CD4(+) T cellsen
dc.typeinfo:eu-repo/semantics/article
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