Kinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3(-/-) mice

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dc.contributor.authorOliveira, F. L.
dc.contributor.authorFrazao, P.
dc.contributor.authorChammas, Roger [UNIFESP]
dc.contributor.authorHsu, D. K.
dc.contributor.authorLiu, F. T.
dc.contributor.authorBorojevic, Radovan
dc.contributor.authorTakiya, C. M.
dc.contributor.authorEl-Cheikh, M. C.
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCEPID FAPESP
dc.contributor.institutionUniv Calif Davis
dc.date.accessioned2016-01-24T13:48:54Z
dc.date.available2016-01-24T13:48:54Z
dc.date.issued2007-08-01
dc.description.abstractGalectin-3 (gal-3), a beta-galactoside-binding animal lectin, plays a role in cell-cell and cell-extracellular matrix interactions. Extracellular gal-3 modulates cell migration and adhesion in several physiological and pathological processes. Gal-3 is highly expressed in activated macrophages. Schistosoma mansoni eggs display a large amount of gal-3 ligands on their surface and elicit a well-characterized, macrophage-dependent, granulomatous, inflammatory reaction. Here, we have investigated the acute and chronic phases of S. mansoni infection in wild-type and gal-3(-/-) mice. in the absence of gal-3, chronic-phase granulomas were smaller in diameter, displaying thinner collagen fibers with a loose orientation. Schistosoma-infected gal-3(-/-) mice had remarkable changes in the monocyte/ macrophage, eosinophil, and B lymphocyte subpopulations as compared with the infected wild- type mice. We observed a reduction of macrophage number, an increase in eosinophil absolute number, and a decrease in B lymphocyte subpopulation (B220(+/high) cells) in the periphery during the evolution of the disease in gal-3(-/-) mice. B lymphopenia was followed by an increase of plasma cell number in bone marrow, spleen, and mesenteric lymph nodes of the infected gal-3(-/-) mice. the plasma IgG and IgE levels also increased in these mice. Gal-3 plays a role in the organization, collagen distribution, and mobilization of inflammatory cells to chronic-phase granulomas, niches for extramedullary myelopoiesis, besides interfering with monocyte-to-macrophage and B cell-to-plasma cell differentiation.en
dc.description.affiliationUniv Fed Rio de Janeiro, Dept Histol & Embriol, Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Fac Med, Expt Oncol Lab, São Paulo, Brazil
dc.description.affiliationCEPID FAPESP, Ctr Cell Based Therapy, São Paulo, Brazil
dc.description.affiliationUniv Calif Davis, Sch Med, Dept Dermatol, Sacramento, CA 95817 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Fac Med, Expt Oncol Lab, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent300-310
dc.identifierhttp://dx.doi.org/10.1189/jlb.1206747
dc.identifier.citationJournal of Leukocyte Biology. Bethesda: Federation Amer Soc Exp Biol, v. 82, n. 2, p. 300-310, 2007.
dc.identifier.doi10.1189/jlb.1206747
dc.identifier.issn0741-5400
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29891
dc.identifier.wosWOS:000248358500016
dc.language.isoeng
dc.publisherFederation Amer Soc Exp Biol
dc.relation.ispartofJournal of Leukocyte Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSchistosoma mansonien
dc.subjectplasma cellsen
dc.subjectmacrophagesen
dc.subjectgranulomaen
dc.titleKinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3(-/-) miceen
dc.typeinfo:eu-repo/semantics/article
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