Inspiratory fraction and exercise impairment in COPD patients GOLD stages II-III

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dc.contributor.authorAlbuquerque, A. L. P. [UNIFESP]
dc.contributor.authorNery, Luiz Eduardo [UNIFESP]
dc.contributor.authorVillaça, Debora Strose [UNIFESP]
dc.contributor.authorMachado, T. Y. S. [UNIFESP]
dc.contributor.authorOliveira, Cristino Carneiro [UNIFESP]
dc.contributor.authorPaes,Ângela Tavares [UNIFESP]
dc.contributor.authorNeder, Jose Alberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:33Z
dc.date.available2016-01-24T12:41:33Z
dc.date.issued2006-11-01
dc.description.abstractThe inspiratory-to-total lung capacity ratio or inspiratory fraction (inspiratory capacity (IC)/total lung capacity (TLC)) may be functionally more representative than traditional indices of resting airflow limitation and lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD).In the present retrospective study, a comparison was made of the individual performance of post-bronchodilator IC, IC/TLC and forced expiratory volume in one second (FEV1) in predicting a severely reduced peak oxygen uptake (V'o(2); < 60% predicted) in 44 COPD patients Global Initiative for Chronic Obstructive Lung Disease stages II-III (post-bronchodilator FEV1 ranging from 31-79% pred).Patients with lower IC/TLC values (<= 0.28) showed increased lung volumes and reduced exercise capacity as compared with other subjects. Following a multiple linear regression analysis, only IC/TLC and FEV1 remained as independent predictors of V'o(2) (r(2)=0.33). A receiver operating characteristic (ROC) curve analysis revealed that an IC/TLC <= 0.28 had the highest specificity (89.6%), positive predictive value (80%) and overall accuracy (86.3%) in identifying patients with V'o(2)< 60% pred. in addition, the area under the ROC curve tended to be higher for IC/TLC than IC.In conclusion, post-bronchodilator total lung capacity-corrected inspiratory fraction provides useful information in addition to forced expiratory volume in one second and inspiratory capacity, to estimate the likelihood of chronic obstructive pulmonary disease patients to present with severely reduced maximal exercise capacity.en
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med, Pulm Funct & Clin Exercise Physiol Unit, Resp Div,Dept Med,EPM, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med, Pulm Funct & Clin Exercise Physiol Unit, Resp Div,Dept Med,EPM, BR-04020050 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent939-944
dc.identifierhttp://dx.doi.org/10.1183/09031936.06.00040506
dc.identifier.citationEuropean Respiratory Journal. Sheffield: European Respiratory Soc Journals Ltd, v. 28, n. 5, p. 939-944, 2006.
dc.identifier.doi10.1183/09031936.06.00040506
dc.identifier.issn0903-1936
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29222
dc.identifier.wosWOS:000241994200011
dc.language.isoeng
dc.publisherEuropean Respiratory Soc Journals Ltd
dc.relation.ispartofEuropean Respiratory Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchronic obstructive pulmonary diseaseen
dc.subjectdyspnoeaen
dc.subjectexerciseen
dc.subjectinspiratory fractionen
dc.subjectlung hyperinflationen
dc.subjectlung volumesen
dc.titleInspiratory fraction and exercise impairment in COPD patients GOLD stages II-IIIen
dc.typeinfo:eu-repo/semantics/article
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