The success of endosseous implants in human immunodeficiency virus-positive patients receiving antiretroviral therapy A pilot study

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dc.contributor.authorOliveira, Marcio Augusto de
dc.contributor.authorGallottini, Marina Helena
dc.contributor.authorPallos, Debora
dc.contributor.authorMaluf, Paulo Sérgio Zaidan [UNIFESP]
dc.contributor.authorJablonka, Fernando
dc.contributor.authorOrtega, Karem Lopez
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T10:46:22Z
dc.date.available2018-06-18T10:46:22Z
dc.date.issued2011-09-01
dc.description.abstractBackground. In a pilot study, the authors aimed to determine the success rate of dental implants placed in patients who were positive for human immunodeficiency virus (HIV) and were receiving different regimens of highly active anti-retroviral therapy (HAART). They considered patients' levels of cluster of differentiation (CD) 4(+) cells and viral load, and they attempted to verify whether patients with baseline biochemical signs of bone mineral density loss could experience osseointegration impairment.Materials and Methods. One of the authors, a dentist, placed dental implants in the posterior mandibles of 40 volunteers, divided into three groups: one composed of HIV-positive patients receiving protease inhibitor (PI)-based HAART; a second composed of HIV-positive patients receiving nonnucleoside reverse transcriptase inhibitor based HAART (without PI); and a control group composed of HIV-negative participants. The authors assessed pen-implant health six and 12 months after implant loading. They analyzed the success of the implants in relation to CD4(+) cell counts, viral load and baseline pyridinoline and deoxypyridinoline values.Results. The authors followed 59 implants for 12 months after loading. Higher baseline levels of pyridinoline and deoxypyridinoline found in HIV-positive participants did not interfere with osseointegration after 12 months of follow-up. Average pen-implant bone loss after 12 months was 0.49 millimeters in group 1, 0.47 mm in group 2, and 0.55 mm in the control group.Conclusions. The placement of dental implants in HIV-positive patients is a reasonable treatment option, regardless of CD4(+) cell count, viral load levels and type of antiretroviral therapy. Longer, follow-up periods are necessary to ascertain the predictability of the long-term success of dental implants in these patients.Clinical Implications. Limited published scientific evidence is available to guide clinicians in regard to possible increased risks associated with dental implant placement in HIV-positive patients.en
dc.description.affiliationUniv Sao Paulo, Dept Oral Pathol, Sch Dent, Special Care Dent Ctr, BR-05508000 Sao Paulo, Brazil
dc.description.affiliationUniv Taubate, Dept Periodontol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Plast Surg, Sao Paulo, Brazil
dc.description.affiliationSao Andre Sao Bernardo Campo & Sao Caetano Cty AB, Dept Hematol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Plast Surg, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 60239-0/2006
dc.format.extent687-692
dc.identifierhttp://dx.doi.org/10.14219/jada.archive.2011.0320
dc.identifier.citationJournal Of The American Dental Association. Chicago: Amer Dental Assoc, v. 142, n. 9, p. 1010-1016, 2011.
dc.identifier.doi10.14219/jada.archive.2011.0320
dc.identifier.issn0002-8177
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44730
dc.identifier.wosWOS:000294973000010
dc.language.isoeng
dc.publisherAmer Dental Assoc
dc.relation.ispartofJournal Of The American Dental Association
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHuman immunodeficiency virusen
dc.subjectAIDSen
dc.subjecthighly active antiretroviral therapyen
dc.subjectdental implantsen
dc.subjectpyridinolineen
dc.subjectdeoxypyridinolineen
dc.titleThe success of endosseous implants in human immunodeficiency virus-positive patients receiving antiretroviral therapy A pilot studyen
dc.typeinfo:eu-repo/semantics/article
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