Proteinase inhibitors in Brazilian leguminosae

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dc.contributor.authorSampaio, Claudio Augusto Machado [UNIFESP]
dc.contributor.authorOliva, Maria Luiza Vilela [UNIFESP]
dc.contributor.authorTanaka, Aparecida Sadae [UNIFESP]
dc.contributor.authorSampaio, Misako Uemura [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUFMS Instituto de Química Departamento de Química
dc.date.accessioned2015-06-14T13:24:21Z
dc.date.available2015-06-14T13:24:21Z
dc.date.issued1991-01-01
dc.description.abstractSerine proteinase inhitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, a digestive enzyme, Factor XIIa and human plasma Kallikrein, two blood clotting factors. The inhibitors were purified from Enterolobium contortisiliquum (Mr=23,000), Torresea cearensis (Mr = 13,000), Bauhinia pentandra (Mr = 20,000) and Bauhinia bauhinioides (Mr = 20,000). E. contortisiliquum inhibitor inactivates all three enzymes, whereas the T. cearensis inhibitor inactivates trypsin and Factor XSSa, but does nor affect plasma kallikrein; both Bauhinia inhibitors, on the other hand, inactivate trypsin and plasma kallikrein but only the Bpentandra inhibitor affects Factor XIIa. Ki values were calculated between 10 [raised to the power of] -7 and 10 [raised to the power of] -8 M.en
dc.description.affiliationEscola Paulista de Medicina Departamento de Bioquímica
dc.description.affiliationUFMS Instituto de Química Departamento de Química
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Bioquímica
dc.description.sourceSciELO
dc.format.extent207-209
dc.identifierhttp://dx.doi.org/10.1590/S0074-02761991000600047
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, p. 207-209, 1991.
dc.identifier.doi10.1590/S0074-02761991000600047
dc.identifier.fileS0074-02761991000600047.pdf
dc.identifier.issn0074-0276
dc.identifier.scieloS0074-02761991000600047
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/275
dc.identifier.wosWOS:A1991GN58900047
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBauhinia bauhinioidesen
dc.subjectBauhinia pentandraen
dc.subjectcoagulationen
dc.subjectEnterolobium contortisiliquumen
dc.subjectproteinase inhibitoren
dc.subjectTorresea cearensisen
dc.titleProteinase inhibitors in Brazilian leguminosaeen
dc.typeinfo:eu-repo/semantics/article
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