Decreased activity of striatal monoamine oxidase B after rapid eye movement (REM) sleep deprivation in rats

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dc.contributor.authorPerez, N. M.
dc.contributor.authorMattei, Rita
dc.contributor.authorVenditti, Marco Antonio Campana [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:34Z
dc.date.available2016-01-24T12:30:34Z
dc.date.issued1998-05-01
dc.description.abstractThe striatum seems to be the main brain region involved in stereotyped behavior induced by dopaminergic agonists. Rapid eye movement (REM) sleep deprivation increases dopaminergic agonist-induced stereotypy and produces biochemical changes in striatal dopaminergic neurotransmission. However, the mechanism underlying the increased dopaminergic sensitivity induced by REM sleep deprivation has not been elucidated. in an attempt to determine some of the biochemical changes in striatal dopaminergic neurotransmission that could contribute to REM sleep deprivation effects, we measured the activity of monoamine oxidase (MAO) A and B, the enzymes responsible for dopamine and beta-phenylethylamine (beta-PEA) deamination in striatum. Male adult rats were deprived of REM sleep for 96 h by the newer-pot technique. MAO A and B were assayed radioisotopically in the mitochondrial fraction by standard laboratory procedures, using [C-14]-5-hydroxytryptamine (5-MT) and [C-14]-beta-phenylethylamine (beta-PEA), as substrates for MAO A and MAO B, respectively. the results showed no significant statistical differences in striatal MAO A activity, whereas a significant decrease in MAO B activity was observed. the results are discussed in terms of the possible involvement of beta-PEA, a striatal endogenous trace amine, which potentiates dopaminergic neurotransmission and may participate in the increased dopaminergic sensitivity observed after REM sleep deprivation. (C) 1998 Elsevier Science Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent33-37
dc.identifierhttp://dx.doi.org/10.1016/S0091-3057(97)00556-X
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 60, n. 1, p. 33-37, 1998.
dc.identifier.doi10.1016/S0091-3057(97)00556-X
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25892
dc.identifier.wosWOS:000073551900006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectREM sleep deprivationen
dc.subjectstriatumen
dc.subjectmonoamine oxidasesen
dc.subjecttyrosine hydroxylaseen
dc.titleDecreased activity of striatal monoamine oxidase B after rapid eye movement (REM) sleep deprivation in ratsen
dc.typeinfo:eu-repo/semantics/article
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