Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases

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dc.citation.volume7
dc.contributor.authorIgnacio, Aline
dc.contributor.authorMorales, Camila Ideli
dc.contributor.authorSaraiva Camara, Niels Olsen [UNIFESP]
dc.contributor.authorAlmeida, Rafael Ribeiro
dc.coverageLausanne
dc.date.accessioned2020-08-21T17:00:22Z
dc.date.available2020-08-21T17:00:22Z
dc.date.issued2016
dc.description.abstractThe mammalian gastrointestinal tract harbors a diverse microbial community with which dynamic interactions have been established over millennia of coevolution. Commensal bacteria and their products are sensed by innate receptors expressed in gut epithelia and in gut-associated immune cells, thereby promoting the proper development of mucosal immune system and host homeostasis. Many studies have demonstrated that host-microbiota interactions play a key role during local and systemic immunity. Therefore, this review will focus on how innate sensing of the gut microbiota and their metabolites through inflammasome and toll-like receptors impact the modulation of a distinct set of inflammatory and autoimmune diseases. We believe that a better understanding of the fine-tuning that governs host-microbiota interactions will further improve common prophylactic and therapeutic applications.en
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Renal Pathophysiol Lab, Dept Clin Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Div Nephrol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq
dc.description.sponsorshipSao Paulo State Research Funding Agency (FAPESP)
dc.description.sponsorshipFAPESP fellowships
dc.description.sponsorshipIDFAPESP: 12/02270-2
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fimmu.2016.00054
dc.identifier.citationFrontiers In Immunology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fimmu.2016.00054
dc.identifier.fileWOS000370412500001.pdf
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57966
dc.identifier.wosWOS:000370412500001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmicrobiotaen
dc.subjecttoll-like receptorsen
dc.subjectinflammasomeen
dc.subjectautoimmunityen
dc.subjectinflammatory diseasesen
dc.titleInnate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseasesen
dc.typeinfo:eu-repo/semantics/article
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