Anti-inflammatory actions of herbal medicines in a model of chronic obstructive pulmonary disease induced by cigarette smoke

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dc.citation.volumev. 99
dc.contributor.authorPossebon, Lucas
dc.contributor.authorLebron, Isabella de Souza Lima
dc.contributor.authorSilva, Ligia Furlan da
dc.contributor.authorPaletta, Julia Tagliaferri
dc.contributor.authorGlad, Bruna Gabrieli
dc.contributor.authorSant'Ana, Monielle [UNIFESP]
dc.contributor.authorIyomasa-Pilon, Melina Mizusaki
dc.contributor.authorSouza, Helena Ribeiro
dc.contributor.authorCosta, Sara de Souza
dc.contributor.authorRodriguesa, Giselda Pereira da Silva
dc.contributor.authorPereira, Maria de Lourdes
dc.contributor.authorMoreno, Andreia de Haro
dc.contributor.authorGirol, Ana Paula
dc.coverageIssy-Les-Moulineaux
dc.date.accessioned2020-07-20T16:31:22Z
dc.date.available2020-07-20T16:31:22Z
dc.date.issued2018
dc.description.abstractThe effects of four medicinal herbs (Arctium lappa, Plantago major, Mikania glomerata Spreng and Equisetum arvense) with anti-inflammatory properties were evaluated in a chronic obstructive pulmonary disease (COPD) model. Wistar rats were exposed to cigarette smoke during 8 weeks and one of the groups was orally given a solution containing 4% of each alcoholic herbal extracts during the exposure period. Control group was not exposed to smoke or treated. Histopathological, immunohistochemical and biochemical analyzes were performed. Normal blood plasma levels of gamma glutamyl transferase indicated no toxicity of the administered herbal extracts. The treatment reduced leukocytes influx in bronchoalveolar lavage, mast cell and macrophages numbers in lungs, as well as prevented pulmonary congestion and tracheal metaplasia. Herbal mixture also decreased plasma inflammatory mediator levels and pulmonary expression of annexin A1 and nuclear factor-k beta. Our data indicate synergistic and protective effects of the used herbal medicines in animals exposed to cigarette smoke as a potential therapeutic strategy.en
dc.description.affiliationIntegrated Coll Padre Albino Fdn FIPA, Catanduva, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci IBILCE, Dept Biol, Lab Immunomorphol, Sao Jose do Rio Preto Campus, Sao Paulo, SP, Brazil
dc.description.affiliationMunicipal Inst Higher Educ Catanduva IMES, Catanduva, SP, Brazil
dc.description.affiliationSao Paulo Fed Univ UNIFESP, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Aveiro, Aveiro Inst Mat, Dept Biol, Aveiro, Portugal
dc.description.affiliationCICECO, Aveiro, Portugal
dc.description.affiliationUnifespSao Paulo Fed Univ UNIFESP, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFaculdades Integradas Padre Albino (FIPA), Catanduva, SP, Brazil
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), SP, Brazil
dc.description.sponsorshipIDFAPESP: 2015/033595
dc.format.extent591-597
dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2018.01.106
dc.identifier.citationBiomedicine & Pharmacotherapy. Issy-Les-Moulineaux, v. 99, p. 591-597, 2018.
dc.identifier.doi10.1016/j.biopha.2018.01.106
dc.identifier.issn0753-3322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55909
dc.identifier.wosWOS:000427436800077
dc.language.isoeng
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCOPDen
dc.subjectHistopathologyen
dc.subjectInflammatory mediatorsen
dc.subjectPhytotherapyen
dc.subjectSmokingen
dc.titleAnti-inflammatory actions of herbal medicines in a model of chronic obstructive pulmonary disease induced by cigarette smokeen
dc.typeinfo:eu-repo/semantics/article
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