Effective Targeting of the Epidermal Growth Factor Receptor (EGFR) for Treating Oral Cancer: A Promising Approach

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dc.contributor.authorRibeiro, Flavia Andressa Pidone [UNIFESP]
dc.contributor.authorNoguti, Juliana [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T13:50:15Z
dc.date.available2018-06-15T13:50:15Z
dc.date.issued2014-04-01
dc.description.abstractOral cancer is a serious problem growing in incidence in many parts of the world; it is considered the sixth most common cancer and despite sophisticated surgical and radiotherapeutic modalities, oral squamous cell carcinoma, which represents 90% of oral cancers, is characterized by poor prognosis and a low survival rate. The Epidermal growth factor receptor family of receptor tyrosine kinases (RTK) comprises of four distinct receptors: the EGFR (also known as ErbB-1/HER1), ErbB-2 (neu, HER2), ErbB-3 (HER3) and ErbB-4 (HER4). Several studies have been published on the role of EGFR in the pathogenesis of oral carcinoma. The aim of the present review is to describe the role of EGFR pathway in oral cancer with special focus on its role during the carcinogenesis process as a result of therapeutic approaches of EGFR in oral cancer. The EGFR is a 170-kDa cell-surface protein involved in many biological processes, such as proliferation, migration, DNA synthesis and adhesion. Overexpression of EGFR results in a poor prognosis in oral cancer and its activation is associated with the malignant phenotype, inhibition of apoptosis and increased metastatic potential. EGFR variations and mutations have been correlated with tumor formation, and possibly alter the therapeutic efficacy of EGFR inhibitors.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1547-1552
dc.identifierhttp://ar.iiarjournals.org/content/34/4/1547.long
dc.identifier.citationAnticancer Research. Athens: Int Inst Anticancer Research, v. 34, n. 4, p. 1547-1552, 2014.
dc.identifier.issn0250-7005
dc.identifier.urihttp://repositorio.unifesp.br/11600/42601
dc.identifier.wosWOS:000334089200009
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofAnticancer Research
dc.rightsAcesso aberto
dc.subjectEpidermal growth factor receptoren
dc.subjectoral canceren
dc.subjectreviewen
dc.titleEffective Targeting of the Epidermal Growth Factor Receptor (EGFR) for Treating Oral Cancer: A Promising Approachen
dc.typeResenha
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