Early exercise promotes positive hippocampal plasticity and improves spatial memory in the adult life of rats

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dc.contributor.authorSilva, Sergio Gomes da [UNIFESP]
dc.contributor.authorUnsain, Nicolas
dc.contributor.authorHugo Masco, Daniel
dc.contributor.authorToscano-Silva, Michelle [UNIFESP]
dc.contributor.authorAmorim, Henrique Alves de [UNIFESP]
dc.contributor.authorSilva Araujo, Bruno Henrique [UNIFESP]
dc.contributor.authorRodrigues Simoes, Priscila Santos [UNIFESP]
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorMortara, Renato Arruda [UNIFESP]
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Nacl Cordoba
dc.date.accessioned2016-01-24T14:17:50Z
dc.date.available2016-01-24T14:17:50Z
dc.date.issued2012-02-01
dc.description.abstractThere is a great deal of evidence showing the capacity of physical exercise to enhance cognitive function, reduce anxiety and depression, and protect the brain against neurodegenerative disorders. Although the effects of exercise are well documented in the mature brain, the influence of exercise in the developing brain has been poorly explored. Therefore, we investigated the morphological and functional hippocampal changes in adult rats submitted to daily treadmill exercise during the adolescent period. Male Wistar rats aged 21 postnatal days old (P21) were divided into two groups: exercise and control. Animals in the exercise group were submitted to daily exercise on the treadmill between P21 and P60. Running time and speed gradually increased over this period, reaching a maximum of 18 m/min for 60 min. After the aerobic exercise program (P60), histological and behavioral (water maze) analyses were performed. the results show that early-life exercise increased mossy fibers density and hippocampal expression of brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B, improved spatial learning and memory, and enhanced capacity to evoke spatial memories in later stages (when measured at P96). It is important to point out that while physical exercise induces hippocampal plasticity, degenerative effects could appear in undue conditions of physical or psychological stress. in this regard, we also showed that the exercise protocol used here did not induce inflammatory response and degenerating neurons in the hippocampal formation of developing rats. Our findings demonstrate that physical exercise during postnatal development results in positive changes for the hippocampal formation, both in structure and function. (C) 2010 Wiley Periodicals, Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Nacl Cordoba, Ctr Cellular & Mol Biol, RA-5000 Cordoba, Argentina
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipINNT
dc.description.sponsorshipClnAPCe
dc.description.sponsorshipIBRO-LARC
dc.format.extent347-358
dc.identifierhttp://dx.doi.org/10.1002/hipo.20903
dc.identifier.citationHippocampus. Malden: Wiley-Blackwell, v. 22, n. 2, p. 347-358, 2012.
dc.identifier.doi10.1002/hipo.20903
dc.identifier.issn1050-9631
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34559
dc.identifier.wosWOS:000299250400021
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofHippocampus
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectexerciseen
dc.subjectbrainen
dc.subjectdevelopmenten
dc.subjectplasticityen
dc.subjecthippocampusen
dc.subjectmemoryen
dc.titleEarly exercise promotes positive hippocampal plasticity and improves spatial memory in the adult life of ratsen
dc.typeinfo:eu-repo/semantics/article
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