Consensus Paper: Radiological Biomarkers of Cerebellar Diseases

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dc.contributor.authorBaldarcara, Leonardo [UNIFESP]
dc.contributor.authorCurrie, Stuart
dc.contributor.authorHadjivassiliou, M.
dc.contributor.authorHoggard, Nigel
dc.contributor.authorJack, Allison
dc.contributor.authorJackowski, Andrea P. [UNIFESP]
dc.contributor.authorMascalchi, Mario
dc.contributor.authorParazzini, Cecilia
dc.contributor.authorReetz, Kathrin
dc.contributor.authorRighini, Andrea
dc.contributor.authorSchulz, Joerg B.
dc.contributor.authorVella, Alessandra
dc.contributor.authorWebb, Sara Jane
dc.contributor.authorHabas, Christophe
dc.contributor.institutionFed Univ Tocantins
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Sheffield
dc.contributor.institutionRoyal Hallamshire Hosp
dc.contributor.institutionYale Univ
dc.contributor.institutionUniv Florence
dc.contributor.institutionMeyer Children & Careggi Hosp Florence
dc.contributor.institutionChildrens Hosp Buzzi
dc.contributor.institutionRWTH Aachen Univ Hosp
dc.contributor.institutionForschungszentrum Julich
dc.contributor.institutionJulich Aachen Res Alliance JARA
dc.contributor.institutionUniv Hosp Siena
dc.contributor.institutionUniv Washington
dc.contributor.institutionCHNO Quinze Vingts
dc.date.accessioned2016-01-24T14:40:18Z
dc.date.available2016-01-24T14:40:18Z
dc.date.issued2015-04-01
dc.description.abstractHereditary and sporadic cerebellar ataxias represent a vast and still growing group of diseases whose diagnosis and differentiation cannot only rely on clinical evaluation. Brain imaging including magnetic resonance (MR) and nuclear medicine techniques allows for characterization of structural and functional abnormalities underlying symptomatic ataxias. These methods thus constitute a potential source of radiological biomarkers, which could be used to identify these diseases and differentiate subgroups of them, and to assess their severity and their evolution. Such biomarkers mainly comprise qualitative and quantitative data obtained from MR including proton spectroscopy, diffusion imaging, tractography, voxel-based morphometry, functional imaging during task execution or in a resting state, and from SPETC and PET with several radiotracers. in the current article, we aim to illustrate briefly some applications of these neuroimaging tools to evaluation of cerebellar disorders such as inherited cerebellar ataxia, fetal developmental malformations, and immune-mediated cerebellar diseases and of neurodegenerative or early-developing diseases, such as dementia and autism in which cerebellar involvement is an emerging feature. Although these radiological biomarkers appear promising and helpful to better understand ataxia-related anatomical and physiological impairments, to date, very few of them have turned out to be specific for a given ataxia with atrophy of the cerebellar system being the main and the most usual alteration being observed. Consequently, much remains to be done to establish sensitivity, specificity, and reproducibility of available MR and nuclear medicine features as diagnostic, progression and surrogate biomarkers in clinical routine.en
dc.description.affiliationFed Univ Tocantins, Tocantins, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Sheffield, Royal Hallamshire Hosp, Acad Unit Radiol, Sheffield S10 2JF, S Yorkshire, England
dc.description.affiliationRoyal Hallamshire Hosp, Acad Dept Neurosci, Sheffield S10 2JF, S Yorkshire, England
dc.description.affiliationYale Univ, Ctr Child Study, New Haven, CT 06520 USA
dc.description.affiliationUniv Florence, Mario Serio Dept Expt & Clin Biomed Sci, Florence, Italy
dc.description.affiliationMeyer Children & Careggi Hosp Florence, Quantitat & Funct Neuroradiol Res Program, Florence, Italy
dc.description.affiliationChildrens Hosp Buzzi, Pediat Radiol & Neuroradiol Dept, Milan, Italy
dc.description.affiliationRWTH Aachen Univ Hosp, Dept Neurol, Aachen, Germany
dc.description.affiliationForschungszentrum Julich, Inst Neurosci & Med INM 4, D-52425 Julich, Germany
dc.description.affiliationJulich Aachen Res Alliance JARA, Translat Brain Med, Aachen, Germany
dc.description.affiliationUniv Hosp Siena, Nucl Med Unit, Policlin Le Scotte, Siena, Italy
dc.description.affiliationUniv Washington, Dept Psychiat & Behav Sci, Seattle Childrens Res Inst, Ctr Child Hlth Behav & Dev, Seattle, WA 98195 USA
dc.description.affiliationCHNO Quinze Vingts, Serv NeuroImagerie, Paris, France
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent175-196
dc.identifierhttp://dx.doi.org/10.1007/s12311-014-0610-3
dc.identifier.citationCerebellum. New York: Springer, v. 14, n. 2, p. 175-196, 2015.
dc.identifier.doi10.1007/s12311-014-0610-3
dc.identifier.issn1473-4222
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38939
dc.identifier.wosWOS:000350897800013
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCerebellum
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectCerebellumen
dc.subjectAtaxiaen
dc.subjectAutismen
dc.subjectDementiaen
dc.subjectRadiological biomarkeren
dc.subjectImmunityen
dc.subjectFetal malformationen
dc.subjectMRIen
dc.subjectfMRIen
dc.subjectSpectroscopyen
dc.subjectDiffusionen
dc.subjectSPECTen
dc.subjectPETen
dc.subjectUltrasounden
dc.titleConsensus Paper: Radiological Biomarkers of Cerebellar Diseasesen
dc.typeinfo:eu-repo/semantics/article
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