Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft

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dc.contributor.authorPelegrine, Andre Antonio
dc.contributor.authorSorgi da Costa, Carlos Eduardo [UNIFESP]
dc.contributor.authorPizzigatti Correa, Maria Elvira
dc.contributor.authorComenalli Marques, Jose Francisco
dc.contributor.institutionSao Leopoldo Mand Res Ctr
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T13:59:40Z
dc.date.available2016-01-24T13:59:40Z
dc.date.issued2010-05-01
dc.description.abstractPurposeThe aim of this study was to evaluate the potential of an autologous bone marrow graft in preserving the alveolar ridges following tooth extraction.MaterialsThirteen patients requiring extractions of 30 upper anterior teeth were enrolled in this study. They were randomized into two groups: seven patients with 15 teeth to be extracted in the test group and six patients with 15 teeth to be extracted in the control group. Hematologists collected 5 ml of bone marrow from the iliac crest of the patients in the test group immediately before the extractions. Following tooth extraction and elevation of a buccal full-thickness flap, titanium screws were positioned throughout the buccal to the lingual plate and were used as reference points for measurement purposes. the sockets were grafted with an autologous bone marrow in the test sites and nothing was grafted in the control sites. After 6 months, the sites were re-opened and bone loss measurements for thickness and height were taken. Additionally, before implant placement, bone cores were harvested and prepared for histologic and histomorphometric evaluation.ResultsThe test group showed better results (P < 0.05) in preserving alveolar ridges for thickness, with 1.14 +/- 0.87 mm (median 1) of bone loss, compared with the control group, which had 2.46 +/- 0.4 mm (median 2.5) of bone loss. the height of bone loss on the buccal plate was also greater in the control group than in the test group (P < 0.05), 1.17 +/- 0.26 mm (median 1) and 0.62+0.51 (median 0.5), respectively. in five locations in the control group, expansion or bone grafting complementary procedures were required to install implants while these procedures were not required for any of the locations in the test group. the histomorphometric analysis showed similar amounts of mineralized bone in both the control and the test groups, 42.87 +/- 11.33% (median 43.75%) and 45.47 +/- 7.21% (median 45%), respectively.ConclusionThese findings suggest that the autologous bone marrow graft can contribute to alveolar bone repair after tooth extraction.To cite this article:Pelegrine AA, da Costa CES, Correa MEP, Marques JFC Jr. Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft.Clin. Oral Impl. Res. 21, 2010; 535-542.doi: 10.1111/j.1600-0501.2009.01891.x.en
dc.description.affiliationSao Leopoldo Mand Res Ctr, Sch Dent, Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Oral Med, Hemoctr, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipIMPLAC Laboratory
dc.description.sponsorshipKIM Laboratory
dc.format.extent535-542
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0501.2009.01891.x
dc.identifier.citationClinical Oral Implants Research. Malden: Wiley-Blackwell, v. 21, n. 5, p. 535-542, 2010.
dc.identifier.doi10.1111/j.1600-0501.2009.01891.x
dc.identifier.issn0905-7161
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32533
dc.identifier.wosWOS:000276467600011
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical Oral Implants Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectbone marrowen
dc.subjectextraction socketsen
dc.subjecthistomorphometryen
dc.subjectosteogenesisen
dc.titleClinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graften
dc.typeinfo:eu-repo/semantics/article
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