Update on Thin Melanoma: Outcome of an International Workshop

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dc.contributor.authorMihic-Probst, Daniela
dc.contributor.authorShea, Chris
dc.contributor.authorDuncan, Lyn
dc.contributor.authorde la Fouchardiere, Arnaud
dc.contributor.authorLandman, Gilles [UNIFESP]
dc.contributor.authorLandsberg, Jennifer
dc.contributor.authorven den Oord, Joost
dc.contributor.authorLowe, Lori
dc.contributor.authorCook, Martin G.
dc.contributor.authorYun, Sook Jung
dc.contributor.authorClarke, Loren
dc.contributor.authorMessina, Jane
dc.contributor.authorElder, David E.
dc.contributor.authorBarnhill, Raymond L.
dc.date.accessioned2019-01-21T10:30:17Z
dc.date.available2019-01-21T10:30:17Z
dc.date.issued2016
dc.description.abstractThe following communication summarizes the proceedings of a 1-day Workshop of the International Melanoma Pathology Study Group, which was devoted to thin melanoma. The definitions and histologic criteria for thin melanoma were reviewed. The principal differential diagnostic problems mentioned included the distinction of thin melanoma from nevi, especially from nevi of special site, irritated nevi, inflamed and regressing nevi, and dysplastic nevi. Histologic criteria for this analysis were discussed and the importance of clinico-pathologic correlation, especially in acral sites, was emphasized. Criteria for the minimal definition of invasion were also discussed. In addition, a new technique of m-RNA expression profiling with 14 genes was presented and facilitated the distinction of thin melanomas from nevus in histologically obvious cases. However, for particular nevi, it was not obvious why the results indicated a malignant lesion. Despite many molecular and other ancillary investigations, Breslow thickness remains the most important prognostic factor in thin melanoma. The prognostic significance of radial (horizontal) and vertical growth phases, Clark level, regression, and mitotic rate were also discussed. Because of the increasing frequency of thin melanomas, there is a great need to develop more refined predictors of thin melanomas with worse clinical outcome.en
dc.description.affiliationUniv Zurich Hosp, Dept Surg Pathol, CH-8091 Zurich, Switzerland
dc.description.affiliationUniv Chicago, Dept Dermatol, Chicago, IL 60637 USA
dc.description.affiliationHarvard Univ, Massachusetts Gen Hosp, Sch Med, Dermatopathol Unit, Boston, MA 02115 USA
dc.description.affiliationUniv Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
dc.description.affiliationUniv Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
dc.description.affiliationMyriad Genetic Labs Inc, Salt Lake City, UT USA
dc.description.affiliationUniv S Florida, Morsani Coll Med, Dept Pathol & Cell Biol, Tampa, FL USA
dc.description.affiliationUniv S Florida, Morsani Coll Med, Dept Dermatol, Tampa, FL USA
dc.description.affiliationHosp Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
dc.description.affiliationCtr Leon Berard, Dept Biopathol, F-69373 Lyon, France
dc.description.affiliationInst Curie, Dept Pathol, Paris, France
dc.description.affiliationUniv Sao Paulo, Escola Paulista Med, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUniv Bonn, Life & Med Sci Inst, Dept Mol Immunol & Cell Biol, Bonn, Germany
dc.description.affiliationKatholieke Univ Leuven, Univ Leuven, Lab Translat Cell & Tissue Res, Leuven, Belgium
dc.description.affiliationKatholieke Univ Leuven, Univ Leuven, Univ Hosp, Leuven, Belgium
dc.description.affiliationRoyal Surrey Cty Hosp, CRUK Manchester Inst, Dept Mol Oncol, Guildford, Surrey, England
dc.description.affiliationChonnam Natl Univ, Sch Med, Dept Dermatol, Gwangju, South Korea
dc.description.affiliationUnifespEscola Paulista de Medicina, Universidade de São Paulo, Brasil
dc.description.sourceWeb of Science
dc.description.sponsorshipCancer Research UK [22308]
dc.format.extent24-29
dc.identifierhttp://dx.doi.org/10.1097/PAP.0000000000000100
dc.identifier.citationAdvances In Anatomic Pathology. Philadelphia, v. 23, n. 1, p. 24-29, 2016.
dc.identifier.doi10.1097/PAP.0000000000000100
dc.identifier.issn1072-4109
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49682
dc.identifier.wosWOS:000366939500003
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAdvances In Anatomic Pathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectthin melanomaen
dc.subjectBreslow thicknessen
dc.subjectmitotic rateen
dc.subjectgrowth phaseen
dc.subjectregressionen
dc.subjectangiotropismCutaneous Malignant-Melanomaen
dc.subjectTumor Progressionen
dc.subjectMetastasisen
dc.subjectPredictorsen
dc.subjectRegressionen
dc.subjectThicknessen
dc.subjectDiagnosisen
dc.subjectSurvivalen
dc.subjectInvasionen
dc.subjectTrendsen
dc.titleUpdate on Thin Melanoma: Outcome of an International Workshopen
dc.typeinfo:eu-repo/semantics/review
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