Chemiexcitation and Its Implications for Disease

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dc.contributor.authorBrash, Douglas E.
dc.contributor.authorGoncalves, Leticia C. P.
dc.contributor.authorBechara, Etelvino José Henriques [UNIFESP]
dc.date.accessioned2018-07-26T12:18:36Z
dc.date.available2018-07-26T12:18:36Z
dc.date.issued2018
dc.description.abstractQuantum mechanics rarely extends to molecular medicine. Recently, the pigment melanin was found to be susceptible to chemiexcitation, in which an electron is chemically excited to a high-energy molecular orbital. In invertebrates, chemiexcitation causes bioluminescenceen
dc.description.abstractin mammals, a higher-energy process involving melanin transfers energy to DNA without photons, creating the lethal and mutagenic cyclobutane pyrimidine dimer that can cause melanoma. This process is initiated by NO center dot and O-2(center dot-) radicals, the formation of which can be triggered by ultraviolet light or inflammation. Several chronic diseases share two properties: inflammation generates these radicals across the tissue, and the diseased cells lie near melanin. We propose that chemiexcitation may be an upstream event in numerous human diseases.en
dc.description.affiliationYale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Dept Dermatol, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Yale Canc Ctr, New Haven, CT 06520 USA
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Bioquim, BR-05513970 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipLEO Foundation, Ballerup, Denmark
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipL'Oreal Inc.
dc.description.sponsorshipCold Spring Harbor Laboratory
dc.description.sponsorshipNational Institute of Arthritis and Musculoskeletal and Skin Diseases
dc.description.sponsorshipIDNIAMS: 1R01AR070851
dc.format.extent527-541
dc.identifierhttp://dx.doi.org/10.1016/j.molmed.2018.04.004
dc.identifier.citationTrends In Molecular Medicine. Oxford, v. 24, n. 6, p. 527-541, 2018.
dc.identifier.doi10.1016/j.molmed.2018.04.004
dc.identifier.issn1471-4914
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45991
dc.identifier.wosWOS:000433237700004
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleChemiexcitation and Its Implications for Diseaseen
dc.typeinfo:eu-repo/semantics/review
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